4und
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==HUMAN ARTD1 (PARP1) - CATALYTIC DOMAIN IN COMPLEX WITH INHIBITOR BMN673== |
| - | + | <StructureSection load='4und' size='340' side='right' caption='[[4und]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4und]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UND OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UND FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2YQ:(8S,9R)-5-FLUORO-8-(4-FLUOROPHENYL)-9-(1-METHYL-1H-1,2,4-TRIAZOL-5-YL)-2,7,8,9-TETRAHYDRO-3H-PYRIDO[4,3,2-DE]PHTHALAZIN-3-ONE'>2YQ</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4und FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4und OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4und RCSB], [http://www.ebi.ac.uk/pdbsum/4und PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Ekblad, T]] | [[Category: Ekblad, T]] | ||
| - | [[Category: Thorsell, A.G]] | ||
| - | [[Category: Tresaugues, L]] | ||
| - | [[Category: Pinto, A.F]] | ||
[[Category: Karlberg, T]] | [[Category: Karlberg, T]] | ||
[[Category: Klepsch, M]] | [[Category: Klepsch, M]] | ||
| - | [[Category: Schuler, H]] | ||
[[Category: Moche, M]] | [[Category: Moche, M]] | ||
| + | [[Category: Pinto, A F]] | ||
| + | [[Category: Schuler, H]] | ||
| + | [[Category: Thorsell, A G]] | ||
| + | [[Category: Tresaugues, L]] | ||
| + | [[Category: Adp-ribosylation]] | ||
| + | [[Category: Dna repair]] | ||
| + | [[Category: Protein-inhibitor complex]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 15:21, 17 June 2015
HUMAN ARTD1 (PARP1) - CATALYTIC DOMAIN IN COMPLEX WITH INHIBITOR BMN673
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