1yw2
From Proteopedia
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|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=PGJ:2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE'>PGJ</scene> | |LIGAND= <scene name='pdbligand=PGJ:2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE'>PGJ</scene> | ||
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span> |
|GENE= Mapk14, Crk1, Csbp1, Csbp2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | |GENE= Mapk14, Crk1, Csbp1, Csbp2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yw2 OCA], [http://www.ebi.ac.uk/pdbsum/1yw2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1yw2 RCSB]</span> | ||
}} | }} | ||
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[[Category: Walter, R L.]] | [[Category: Walter, R L.]] | ||
[[Category: Xu, S C.]] | [[Category: Xu, S C.]] | ||
| - | [[Category: PGJ]] | ||
[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:24:41 2008'' |
Revision as of 22:24, 30 March 2008
| |||||||
| , resolution 2.01Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | Mapk14, Crk1, Csbp1, Csbp2 (Mus musculus) | ||||||
| Activity: | Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Mutated Mus Musculus P38 Kinase (mP38)
Overview
4-Aryl-3-pyridyl and 4-aryl-3-pyrimidinyl based tumor necrosis factor-alpha (TNF-alpha) inhibitors, which contain a novel isoxazolone five-membered heterocyclic core are described. Many showed sub-micromolar activity against lipopolysaccharide-induced TNF-alpha production.
About this Structure
1YW2 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-alpha) production., Laughlin SK, Clark MP, Djung JF, Golebiowski A, Brugel TA, Sabat M, Bookland RG, Laufersweiler MJ, VanRens JC, Townes JA, De B, Hsieh LC, Xu SC, Walter RL, Mekel MJ, Janusz MJ, Bioorg Med Chem Lett. 2005 May 2;15(9):2399-403. PMID:15837333
Page seeded by OCA on Mon Mar 31 01:24:41 2008
Categories: Mus musculus | Non-specific serine/threonine protein kinase | Single protein | Bookland, R G. | Brugel, T A. | Clark, M P. | De, B. | Djung, J F. | Golebiowski, A. | Hsieh, L C. | Janusz, M J. | Laufersweiler, M J. | Laughlin, S K. | Mekel, M J. | Sabat, M. | Townes, J A. | Vanrens, J C. | Walter, R L. | Xu, S C. | Transferase
