This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4uya
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | ''' | + | ==Structure of MLK4 kinase domain with ATPgammaS== |
| - | + | <StructureSection load='4uya' size='340' side='right' caption='[[4uya]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4uya]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UYA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UYA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uy9|4uy9]]</td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase_kinase Mitogen-activated protein kinase kinase kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.25 2.7.11.25] </span></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uya OCA], [http://pdbe.org/4uya PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uya RCSB], [http://www.ebi.ac.uk/pdbsum/4uya PDBsum]</span></td></tr> |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/M3KL4_HUMAN M3KL4_HUMAN]] Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.<ref>PMID:21602844</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Mitogen-activated protein kinase kinase kinase]] | ||
| + | [[Category: Brassington, C]] | ||
| + | [[Category: Collier, M]] | ||
[[Category: Green, I]] | [[Category: Green, I]] | ||
| - | [[Category: | + | [[Category: Overmann, R]] |
[[Category: Phillips, C]] | [[Category: Phillips, C]] | ||
| - | [[Category: Pollard, H | + | [[Category: Pollard, H K]] |
| - | [[Category: | + | [[Category: Read, J A]] |
| - | [[Category: | + | [[Category: Atp-binding]] |
| + | [[Category: Leucine zipper 1]] | ||
| + | [[Category: Mixed-lineage kinase]] | ||
| + | [[Category: Nucleotide-binding]] | ||
| + | [[Category: Phosphoprotein]] | ||
| + | [[Category: Serine/threonine-protein kinase]] | ||
| + | [[Category: Sh3 domain]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 14:39, 30 September 2015
Structure of MLK4 kinase domain with ATPgammaS
| |||||||||||
Categories: Mitogen-activated protein kinase kinase kinase | Brassington, C | Collier, M | Green, I | Overmann, R | Phillips, C | Pollard, H K | Read, J A | Atp-binding | Leucine zipper 1 | Mixed-lineage kinase | Nucleotide-binding | Phosphoprotein | Serine/threonine-protein kinase | Sh3 domain | Transferase
