4mf8
From Proteopedia
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==Structure of human DNA polymerase beta complexed with nicked DNA containing a mismatched template O6MG and incoming CTP== | ==Structure of human DNA polymerase beta complexed with nicked DNA containing a mismatched template O6MG and incoming CTP== | ||
<StructureSection load='4mf8' size='340' side='right' caption='[[4mf8]], [[Resolution|resolution]] 2.32Å' scene=''> | <StructureSection load='4mf8' size='340' side='right' caption='[[4mf8]], [[Resolution|resolution]] 2.32Å' scene=''> | ||
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=6OG:6-O-METHYL+GUANOSINE-5-MONOPHOSPHATE'>6OG</scene></td></tr> | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=6OG:6-O-METHYL+GUANOSINE-5-MONOPHOSPHATE'>6OG</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3isb|3isb]], [[1bpx|1bpx]], [[4mf2|4mf2]], [[4mfa|4mfa]], [[4mfc|4mfc]], [[4mff|4mff]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3isb|3isb]], [[1bpx|1bpx]], [[4mf2|4mf2]], [[4mfa|4mfa]], [[4mfc|4mfc]], [[4mff|4mff]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mf8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mf8 RCSB], [http://www.ebi.ac.uk/pdbsum/4mf8 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mf8 OCA], [http://pdbe.org/4mf8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mf8 RCSB], [http://www.ebi.ac.uk/pdbsum/4mf8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mf8 ProSAT]</span></td></tr> |
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN]] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref> | [[http://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN]] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref> | ||
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| + | ==See Also== | ||
| + | *[[DNA polymerase|DNA polymerase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 19:43, 4 August 2016
Structure of human DNA polymerase beta complexed with nicked DNA containing a mismatched template O6MG and incoming CTP
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