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4w5v
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal structure of Human SUMO E2-conjugating enzyme (Ubc9) in complex with E1-activating enzyme (Uba2) ubiquitin fold domain (Ufd)== |
| - | + | <StructureSection load='4w5v' size='340' side='right' caption='[[4w5v]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4w5v]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W5V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4W5V FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w5v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4w5v RCSB], [http://www.ebi.ac.uk/pdbsum/4w5v PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[ | + | == Function == |
| - | [[ | + | [[http://www.uniprot.org/uniprot/UBC9_HUMAN UBC9_HUMAN]] Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation.<ref>PMID:8668529</ref> <ref>PMID:11451954</ref> <ref>PMID:15809060</ref> <ref>PMID:19744555</ref> <ref>PMID:19638400</ref> <ref>PMID:17466333</ref> <ref>PMID:20077568</ref> [[http://www.uniprot.org/uniprot/SAE2_HUMAN SAE2_HUMAN]] The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.<ref>PMID:11481243</ref> <ref>PMID:11451954</ref> <ref>PMID:19443651</ref> <ref>PMID:15660128</ref> <ref>PMID:17643372</ref> <ref>PMID:20164921</ref> |
| - | [[ | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Bosch, J]] | [[Category: Bosch, J]] | ||
| - | [[Category: Reiter, K | + | [[Category: Boucher, L E]] |
| + | [[Category: Matunis, M J]] | ||
| + | [[Category: Reiter, K H]] | ||
| + | [[Category: E1-conjugating enzyme]] | ||
| + | [[Category: E2-activating enzyme]] | ||
| + | [[Category: Ligase]] | ||
| + | [[Category: Sumo]] | ||
| + | [[Category: Uba2]] | ||
| + | [[Category: Ubc9]] | ||
| + | [[Category: Ubiquitin]] | ||
| + | [[Category: Ubiquitin fold domain]] | ||
| + | [[Category: Ufd]] | ||
Revision as of 11:18, 9 September 2015
Crystal structure of Human SUMO E2-conjugating enzyme (Ubc9) in complex with E1-activating enzyme (Uba2) ubiquitin fold domain (Ufd)
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Categories: Bosch, J | Boucher, L E | Matunis, M J | Reiter, K H | E1-conjugating enzyme | E2-activating enzyme | Ligase | Sumo | Uba2 | Ubc9 | Ubiquitin | Ubiquitin fold domain | Ufd
