1z11
From Proteopedia
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|PDB= 1z11 |SIZE=350|CAPTION= <scene name='initialview01'>1z11</scene>, resolution 2.05Å | |PDB= 1z11 |SIZE=350|CAPTION= <scene name='initialview01'>1z11</scene>, resolution 2.05Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=8MO:METHOXSALEN'>8MO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span> |
|GENE= CYP2A6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= CYP2A6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1pq2|1PQ2]], [[1r9o|1R9O]], [[1tqn|1TQN]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z11 OCA], [http://www.ebi.ac.uk/pdbsum/1z11 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z11 RCSB]</span> | ||
}} | }} | ||
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==Overview== | ==Overview== | ||
Human microsomal cytochrome P450 2A6 (CYP2A6) contributes extensively to nicotine detoxication but also activates tobacco-specific procarcinogens to mutagenic products. The CYP2A6 structure shows a compact, hydrophobic active site with one hydrogen bond donor, Asn297, that orients coumarin for regioselective oxidation. The inhibitor methoxsalen effectively fills the active site cavity without substantially perturbing the structure. The structure should aid the design of inhibitors to reduce smoking and tobacco-related cancers. | Human microsomal cytochrome P450 2A6 (CYP2A6) contributes extensively to nicotine detoxication but also activates tobacco-specific procarcinogens to mutagenic products. The CYP2A6 structure shows a compact, hydrophobic active site with one hydrogen bond donor, Asn297, that orients coumarin for regioselective oxidation. The inhibitor methoxsalen effectively fills the active site cavity without substantially perturbing the structure. The structure should aid the design of inhibitors to reduce smoking and tobacco-related cancers. | ||
| - | |||
| - | ==Disease== | ||
| - | Known diseases associated with this structure: Coumarin resistance OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=122720 122720]], Lung cancer, resistance to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=122720 122720]], Nicotine addiction, protection from OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=122720 122720]] | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Stout, C D.]] | [[Category: Stout, C D.]] | ||
[[Category: Yano, J K.]] | [[Category: Yano, J K.]] | ||
| - | [[Category: 8MO]] | ||
| - | [[Category: HEM]] | ||
[[Category: coumarin 7-hydroxylase]] | [[Category: coumarin 7-hydroxylase]] | ||
[[Category: cyp2a6]] | [[Category: cyp2a6]] | ||
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[[Category: p450 2a6]] | [[Category: p450 2a6]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:27:31 2008'' |
Revision as of 22:27, 30 March 2008
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| , resolution 2.05Å | |||||||
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| Ligands: | , | ||||||
| Gene: | CYP2A6 (Homo sapiens) | ||||||
| Activity: | Unspecific monooxygenase, with EC number 1.14.14.1 | ||||||
| Related: | 1PQ2, 1R9O, 1TQN
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of Human Microsomal P450 2A6 with Methoxsalen Bound
Overview
Human microsomal cytochrome P450 2A6 (CYP2A6) contributes extensively to nicotine detoxication but also activates tobacco-specific procarcinogens to mutagenic products. The CYP2A6 structure shows a compact, hydrophobic active site with one hydrogen bond donor, Asn297, that orients coumarin for regioselective oxidation. The inhibitor methoxsalen effectively fills the active site cavity without substantially perturbing the structure. The structure should aid the design of inhibitors to reduce smoking and tobacco-related cancers.
About this Structure
1Z11 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen., Yano JK, Hsu MH, Griffin KJ, Stout CD, Johnson EF, Nat Struct Mol Biol. 2005 Sep;12(9):822-3. Epub 2005 Aug 7. PMID:16086027
Page seeded by OCA on Mon Mar 31 01:27:31 2008
