1z53
From Proteopedia
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|PDB= 1z53 |SIZE=350|CAPTION= <scene name='initialview01'>1z53</scene>, resolution 1.13Å | |PDB= 1z53 |SIZE=350|CAPTION= <scene name='initialview01'>1z53</scene>, resolution 1.13Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=PP9:PROTOPORPHYRIN IX'>PP9</scene> | + | |LIGAND= <scene name='pdbligand=PP9:PROTOPORPHYRIN+IX'>PP9</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Cytochrome-c_peroxidase Cytochrome-c peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.5 1.11.1.5] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cytochrome-c_peroxidase Cytochrome-c peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.5 1.11.1.5] </span> |
|GENE= CCP1, CCP, CPO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]) | |GENE= CCP1, CCP, CPO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2cyp|2CYP]], [[1kok|1KOK]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z53 OCA], [http://www.ebi.ac.uk/pdbsum/1z53 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z53 RCSB]</span> | ||
}} | }} | ||
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[[Category: Bhaskar, B.]] | [[Category: Bhaskar, B.]] | ||
[[Category: Poulos, T L.]] | [[Category: Poulos, T L.]] | ||
| - | [[Category: PP9]] | ||
[[Category: ccp]] | [[Category: ccp]] | ||
[[Category: heme peroxidase]] | [[Category: heme peroxidase]] | ||
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[[Category: trp cation radical]] | [[Category: trp cation radical]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:29:11 2008'' |
Revision as of 22:29, 30 March 2008
| |||||||
| , resolution 1.13Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | CCP1, CCP, CPO (Saccharomyces cerevisiae) | ||||||
| Activity: | Cytochrome-c peroxidase, with EC number 1.11.1.5 | ||||||
| Related: | 2CYP, 1KOK
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
The 1.13 Angstrom Structure of Iron-free Cytochrome c Peroxidase
Overview
The iron-free cytochrome c peroxidase (CCP) crystal structure has been determined to 1.13 A and compared with the 1.2-A ferric-CCP structure. Quite unexpectedly, removal of the iron has no effect on porphyrin geometry and distortion, indicating that protein-porphyrin interactions and not iron coordination or formation of the axial His-Fe bond determines porphyrin conformation. However, there are changes in solvent structure in the distal pocket, which lead to changes in the distal His52 acid-base catalyst. The observed ability of His52 to move in response to small changes in solvent structure is very likely important for its role as a catalyst in assisting in the heterolytic fission of the peroxide O-O bond.
About this Structure
1Z53 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
The 1.13-A structure of iron-free cytochrome c peroxidase., Bhaskar B, Poulos TL, J Biol Inorg Chem. 2005 Jun;10(4):425-30. Epub 2005 May 18. PMID:15900441
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