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4whw
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Direct photocapture of bromodomains using tropolone chemical probes== | |
| + | <StructureSection load='4whw' size='340' side='right' caption='[[4whw]], [[Resolution|resolution]] 1.34Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4whw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WHW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WHW FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3OT:2-METHOXY-4-{1-[2-(MORPHOLIN-4-YL)ETHYL]-2-(2-PHENYLETHYL)-1H-BENZIMIDAZOL-5-YL}CYCLOHEPTA-2,4,6-TRIEN-1-ONE'>3OT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4whw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4whw OCA], [http://pdbe.org/4whw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4whw RCSB], [http://www.ebi.ac.uk/pdbsum/4whw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4whw ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Bromodomain-containing protein|Bromodomain-containing protein]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Basak, A]] | ||
| + | [[Category: Bonin, P D]] | ||
| + | [[Category: Chekler, E L.Piatnitski]] | ||
| + | [[Category: Denny, R A]] | ||
| + | [[Category: Flick, A C]] | ||
| + | [[Category: Geoghegan, K F]] | ||
| + | [[Category: Hett, E C]] | ||
| + | [[Category: Jones, L H]] | ||
| + | [[Category: Liu, S]] | ||
| + | [[Category: Pletcher, M T]] | ||
| + | [[Category: Robinson, R P]] | ||
[[Category: Sahasrabudhe, P]] | [[Category: Sahasrabudhe, P]] | ||
[[Category: Salter, S]] | [[Category: Salter, S]] | ||
| - | + | [[Category: Stock, I A]] | |
| - | + | [[Category: Brd4]] | |
| - | + | [[Category: Bromo domain]] | |
| - | [[Category: Stock, I | + | [[Category: Inhibitor]] |
| - | [[Category: | + | [[Category: Transcription-transcription inhibitor complex]] |
| - | [[Category: | + | |
| - | [[Category: | + | |
| - | [[Category: | + | |
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Revision as of 16:52, 18 August 2017
Direct photocapture of bromodomains using tropolone chemical probes
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