1z77
From Proteopedia
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|PDB= 1z77 |SIZE=350|CAPTION= <scene name='initialview01'>1z77</scene>, resolution 2.00Å | |PDB= 1z77 |SIZE=350|CAPTION= <scene name='initialview01'>1z77</scene>, resolution 2.00Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene> | + | |LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1309 AcrR], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00440 TetR_N]</span> | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z77 OCA], [http://www.ebi.ac.uk/pdbsum/1z77 PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=1z77 RCSB]</span> | ||
}} | }} | ||
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[[Category: Minor, W.]] | [[Category: Minor, W.]] | ||
[[Category: Zimmerman, M D.]] | [[Category: Zimmerman, M D.]] | ||
| - | [[Category: EDO]] | ||
[[Category: mcsg]] | [[Category: mcsg]] | ||
[[Category: midwest center for structural genomic]] | [[Category: midwest center for structural genomic]] | ||
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[[Category: transcriptional regulator]] | [[Category: transcriptional regulator]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 06:17:29 2008'' |
Revision as of 04:17, 26 March 2008
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| , resolution 2.00Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Domains: | AcrR, TetR_N | ||||||
| Resources: | FirstGlance, OCA, PDBsum, JenaLib, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of transcriptional regulator protein from Thermotoga maritima.
Overview
The crystal structure of a putative transcriptional regulator protein TM1030 from Thermotoga maritima, a hyperthermophilic bacterium, was determined by an unusual multi-wavelength anomalous dispersion method at 2.0 A resolution, in which data from two different crystals and two different beamlines were used. The protein belongs to the tetracycline repressor TetR superfamily. The three-dimensional structure of TM1030 is similar to the structures of proteins that function as multidrug-binding transcriptional repressors, and contains a large solvent-exposed pocket similar to the drug-binding pockets present in those repressors. The asymmetric unit in the crystal structure contains a single protein chain and the twofold symmetry of the dimer is adopted by the crystal symmetry. The structure described in this paper is an apo- form of TM1030. Although it is known that the protein is significantly overexpressed during heat shock, its detailed function cannot be yet explained.
About this Structure
1Z77 is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.
Reference
Crystal structure of a transcriptional regulator TM1030 from Thermotoga maritima solved by an unusual MAD experiment., Koclega KD, Chruszcz M, Zimmerman MD, Cymborowski M, Evdokimova E, Minor W, J Struct Biol. 2007 Sep;159(3):424-32. Epub 2007 May 16. PMID:17588774
Page seeded by OCA on Wed Mar 26 06:17:29 2008
Categories: Single protein | Thermotoga maritima | Chruszcz, M. | Cymborowski, M. | Koclega, K D. | Kudritska, M. | MCSG, Midwest Center for Structural Genomics. | Minor, W. | Zimmerman, M D. | Mcsg | Midwest center for structural genomic | Protein structure initiative | Psi | Structural genomic | Tetr family | Transcriptional regulator
