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4wlq

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'''Unreleased structure'''
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==Crystal structure of mUCH37-hRPN13 CTD complex==
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<StructureSection load='4wlq' size='340' side='right' caption='[[4wlq]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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The entry 4wlq is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4wlq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WLQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WLQ FirstGlance]. <br>
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Authors: Hemmis, C.W., Hill, C.P., VanderLinden, R., Whitby, F.G.
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wlp|4wlp]], [[4wlr|4wlr]]</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>
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Description:
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wlq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wlq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wlq RCSB], [http://www.ebi.ac.uk/pdbsum/4wlq PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Whitby, F.G]]
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== Function ==
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[[Category: Hill, C.P]]
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[[http://www.uniprot.org/uniprot/UCHL5_MOUSE UCHL5_MOUSE]] Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 (By similarity). [[http://www.uniprot.org/uniprot/ADRM1_HUMAN ADRM1_HUMAN]] Functions as a proteasomal ubiquitin receptor. Recruits the deubiquitinating enzyme UCHL5 at the 26S proteasome and promotes its activity.<ref>PMID:16990800</ref> <ref>PMID:17139257</ref> <ref>PMID:16815440</ref> <ref>PMID:16906146</ref> <ref>PMID:18497817</ref>
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[[Category: Vanderlinden, R]]
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== References ==
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[[Category: Hemmis, C.W]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Ubiquitinyl hydrolase 1]]
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[[Category: Hemmis, C W]]
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[[Category: Hill, C P]]
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[[Category: VanderLinden, R]]
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[[Category: Whitby, F G]]
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[[Category: Uch37 rpn13 proteasome ino80 dub]]

Revision as of 11:37, 4 March 2015

Crystal structure of mUCH37-hRPN13 CTD complex

4wlq, resolution 2.85Å

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