4wqp
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal structure of RORc in complex with a benzyl sulfonamide inverse agonist== |
| - | + | <StructureSection load='4wqp' size='340' side='right' caption='[[4wqp]], [[Resolution|resolution]] 1.99Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4wqp]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WQP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WQP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3SX:N-[4-(4-ACETYLPIPERAZIN-1-YL)BENZYL]-N-(2-METHYLPROPYL)-1-PHENYLMETHANESULFONAMIDE'>3SX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wqp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wqp RCSB], [http://www.ebi.ac.uk/pdbsum/4wqp PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[ | + | == Function == |
| - | [[ | + | [[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Boenig, G]] | [[Category: Boenig, G]] | ||
| + | [[Category: Hymowitz, S G]] | ||
| + | [[Category: Nuclear receptor ligand binding domain]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 13:48, 14 January 2015
Crystal structure of RORc in complex with a benzyl sulfonamide inverse agonist
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