1zfd
From Proteopedia
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|PDB= 1zfd |SIZE=350|CAPTION= <scene name='initialview01'>1zfd</scene> | |PDB= 1zfd |SIZE=350|CAPTION= <scene name='initialview01'>1zfd</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | + | |LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zfd OCA], [http://www.ebi.ac.uk/pdbsum/1zfd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zfd RCSB]</span> | ||
}} | }} | ||
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[[Category: Rhodes, D.]] | [[Category: Rhodes, D.]] | ||
[[Category: Schwabe, J W.R.]] | [[Category: Schwabe, J W.R.]] | ||
| - | [[Category: ZN]] | ||
[[Category: dna binding motif]] | [[Category: dna binding motif]] | ||
[[Category: zinc finger dna binding domain]] | [[Category: zinc finger dna binding domain]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:35:15 2008'' |
Revision as of 22:35, 30 March 2008
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| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
SWI5 ZINC FINGER DOMAIN 2, NMR, 45 STRUCTURES
Overview
This paper describes the detailed three-dimensional structures of two zinc-finger domains from the yeast transcription factor SWI5, calculated using the results of the n.m.r. experiments described in the accompanying paper. The structure of finger 2 is essentially similar to those previously obtained by others for isolated, synthetic single zinc-finger domains in solution, and for the three zinc-finger peptide Zif268 in its crystalline complex with DNA. The N-terminal half of the sequence forms a two-stranded, irregular beta-sheet containing both of the metal-binding cysteine residues, while the remainder of the structure forms a helix. Approximately the first half of this helix is alpha-helical, whereas the C-terminal portion, including the two metal-binding histidine residues, is 3(10) helical. Four invariant hydrophobic residues form a core to the structure. In contrast to all previously described structures of zinc-finger domains, finger 1 has an additional strand in the beta-sheet, formed by residues N-terminal to the formal start of the finger motif. This additional strand plays a role in stabilising the folded form of finger 1, since a two-finger peptide lacking the N-terminal residues showed folded structure in finger 2 but not in finger 1.
About this Structure
1ZFD is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Solution structures of two zinc-finger domains from SWI5 obtained using two-dimensional 1H nuclear magnetic resonance spectroscopy. A zinc-finger structure with a third strand of beta-sheet., Neuhaus D, Nakaseko Y, Schwabe JW, Klug A, J Mol Biol. 1992 Nov 20;228(2):637-51. PMID:1453468
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