1zhu
From Proteopedia
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|PDB= 1zhu |SIZE=350|CAPTION= <scene name='initialview01'>1zhu</scene> | |PDB= 1zhu |SIZE=350|CAPTION= <scene name='initialview01'>1zhu</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=DA:2'-DEOXYADENOSINE-5'-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zhu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zhu OCA], [http://www.ebi.ac.uk/pdbsum/1zhu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zhu RCSB]</span> | ||
}} | }} | ||
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[[Category: triplet disease]] | [[Category: triplet disease]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:36:49 2008'' |
Revision as of 22:36, 30 March 2008
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| Ligands: | , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
DNA (5'-D(*CP*AP*AP*TP*GP*CP*AP*AP*TP*G)-3'), NMR, 10 STRUCTURES
Overview
In certain contexts the DNA triplet GGA, when juxtaposed on opposite strands of a DNA duplex, shows the unusual property of pairing with itself in an antiparallel orientation to form the (GGA)2 motif. In this motif the central guanines do not pair but intercalate and stack between sheared G.A pairs. Similar studies with GCA triplets reveal that they do not form analogous paired (GCA)2 motifs but instead strongly promote formation of a hairpin, the structure of which is now reported here. The GCA hairpin loop consists of a single cytidine residue closed by a sheared G.A pair and this structure is discussed in the context of triplet expansions in triplet-repeat diseases.
About this Structure
1ZHU is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Structure of a single-cytidine hairpin loop formed by the DNA triplet GCA., Zhu L, Chou SH, Xu J, Reid BR, Nat Struct Biol. 1995 Nov;2(11):1012-7. PMID:7583654
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