4x3e

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'''Unreleased structure'''
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==Crystal structure of EED in complex with a trimethylated Jarid2 peptide==
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<StructureSection load='4x3e' size='340' side='right' caption='[[4x3e]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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The entry 4x3e is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4x3e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X3E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X3E FirstGlance]. <br>
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Authors: Justin, N., Gamblin, S.J., Margueron, R.
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x3e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4x3e RCSB], [http://www.ebi.ac.uk/pdbsum/4x3e PDBsum]</span></td></tr>
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Description: Crystal structure of EED in complex with a trimethylated Jarid2 peptide
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</table>
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[[Category: Unreleased Structures]]
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== Function ==
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[[Category: Margueron, R]]
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[[http://www.uniprot.org/uniprot/EED_HUMAN EED_HUMAN]] Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.<ref>PMID:9584199</ref> <ref>PMID:10581039</ref> <ref>PMID:14532106</ref> <ref>PMID:15385962</ref> <ref>PMID:15231737</ref> <ref>PMID:15225548</ref> <ref>PMID:16357870</ref> <ref>PMID:18285464</ref> <ref>PMID:20974918</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Gamblin, S J]]
[[Category: Justin, N]]
[[Category: Justin, N]]
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[[Category: Gamblin, S.J]]
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[[Category: Margueron, R]]
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[[Category: Gene regulation]]
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[[Category: Histone binding]]
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[[Category: Transcription]]
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[[Category: Wd40]]

Revision as of 17:01, 21 January 2015

Crystal structure of EED in complex with a trimethylated Jarid2 peptide

4x3e, resolution 2.30Å

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