4x6c

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'''Unreleased structure'''
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==Immune complex==
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<StructureSection load='4x6c' size='340' side='right' caption='[[4x6c]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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The entry 4x6c is ON HOLD
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4x6c]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X6C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X6C FirstGlance]. <br>
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Authors: Birkinshaw, R.W., Rossjohn, J.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=42H:(4R,7R,18Z)-4,7-DIHYDROXY-N,N,N-TRIMETHYL-10-OXO-3,5,9-TRIOXA-4-PHOSPHAHEPTACOS-18-EN-1-AMINIUM+4-OXIDE'>42H</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4x6d|4x6d]], [[4x6b|4x6b]], [[4x6e|4x6e]], [[4x6f|4x6f]]</td></tr>
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Description:
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x6c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4x6c RCSB], [http://www.ebi.ac.uk/pdbsum/4x6c PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/CD1A_HUMAN CD1A_HUMAN]] Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:11231314</ref> <ref>PMID:16272286</ref> <ref>PMID:18178838</ref> [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Birkinshaw, R W]]
[[Category: Rossjohn, J]]
[[Category: Rossjohn, J]]
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[[Category: Birkinshaw, R.W]]
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[[Category: Cd1a]]
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[[Category: Immune complex]]
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[[Category: Immune system]]
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[[Category: Lipid antigen]]
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[[Category: Tcr]]

Revision as of 16:50, 28 January 2015

Immune complex

4x6c, resolution 2.80Å

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