1qce

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<StructureSection load='1qce' size='340' side='right' caption='[[1qce]], [[NMR_Ensembles_of_Models | 30 NMR models]]' scene=''>
<StructureSection load='1qce' size='340' side='right' caption='[[1qce]], [[NMR_Ensembles_of_Models | 30 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1qce]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Simian_immunodeficiency_virus Simian immunodeficiency virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QCE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QCE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1qce]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Civ Civ]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QCE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QCE FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qce OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qce RCSB], [http://www.ebi.ac.uk/pdbsum/1qce PDBsum]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qce OCA], [http://pdbe.org/1qce PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qce RCSB], [http://www.ebi.ac.uk/pdbsum/1qce PDBsum]</span></td></tr>
</table>
</table>
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== Function ==
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{{Large structure}}
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[[http://www.uniprot.org/uniprot/Q88031_SIVCZ Q88031_SIVCZ]] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).[SAAS:SAAS000328_004_240990]
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== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Simian immunodeficiency virus]]
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[[Category: Civ]]
[[Category: Clore, G M]]
[[Category: Clore, G M]]
[[Category: Siv gp41 ectodomain]]
[[Category: Siv gp41 ectodomain]]
[[Category: Viral protein]]
[[Category: Viral protein]]
[[Category: Virus envelope protein]]
[[Category: Virus envelope protein]]

Revision as of 10:05, 10 September 2015

SOLUTION NMR STRUCTURE OF ECTODOMAIN OF SIV GP41, RESTRAINED REGULARIZED MEAN STRUCTURE PLUS 29 SIMULATED ANNEALING STRUCTURES

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