3dbo
From Proteopedia
(Difference between revisions)
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<StructureSection load='3dbo' size='340' side='right' caption='[[3dbo]], [[Resolution|resolution]] 1.76Å' scene=''> | <StructureSection load='3dbo' size='340' side='right' caption='[[3dbo]], [[Resolution|resolution]] 1.76Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3dbo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3dbo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DBO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DBO FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rv0626, MT0654 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rv0626, MT0654 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU]), Rv0627 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dbo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dbo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dbo RCSB], [http://www.ebi.ac.uk/pdbsum/3dbo PDBsum], [http://www.topsan.org/Proteins/ISFI/3dbo TOPSAN]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dbo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dbo OCA], [http://pdbe.org/3dbo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dbo RCSB], [http://www.ebi.ac.uk/pdbsum/3dbo PDBsum], [http://www.topsan.org/Proteins/ISFI/3dbo TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/ | + | [[http://www.uniprot.org/uniprot/VAPB5_MYCTO VAPB5_MYCTO]] Probable antitoxin component of a probable toxin-antitoxin (TA) module. The cognate toxin is VapC5 (By similarity). [[http://www.uniprot.org/uniprot/VAPC5_MYCTU VAPC5_MYCTU]] Probable toxic component of a type II toxin-antitoxin (TA) module. The cognate antitoxin is VapB5. Has limited RNase activity on substrates; activity is seen with a VapC5-VapB5 complex.<ref>PMID:18952600</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dbo ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 3dbo" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Myctu]] |
[[Category: Cascio, D]] | [[Category: Cascio, D]] | ||
[[Category: Eisenberg, D]] | [[Category: Eisenberg, D]] | ||
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[[Category: Integrated center for structure and function innovation]] | [[Category: Integrated center for structure and function innovation]] | ||
[[Category: Isfi]] | [[Category: Isfi]] | ||
| + | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: PSI, Protein structure initiative]] | [[Category: PSI, Protein structure initiative]] | ||
[[Category: Tbsgc]] | [[Category: Tbsgc]] | ||
Revision as of 09:54, 8 February 2016
Crystal structure of a member of the VapBC family of toxin-antitoxin systems, VapBC-5, from Mycobacterium tuberculosis
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Categories: Myctu | Cascio, D | Eisenberg, D | ISFI, Integrated Center for Structure and Function Innovation | Miallau, L | Structural genomic | Integrated center for structure and function innovation | Isfi | Mycobacterium tuberculosis | PSI, Protein structure initiative | Tbsgc | Toxin antitoxin complex | Toxin-antitoxin complex | Vapbc
