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4hlf

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==Crystal structure of Tankyrase 2 in complex with 7,3',4'-Trihydroxyflavone==
==Crystal structure of Tankyrase 2 in complex with 7,3',4'-Trihydroxyflavone==
<StructureSection load='4hlf' size='340' side='right' caption='[[4hlf]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
<StructureSection load='4hlf' size='340' side='right' caption='[[4hlf]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4hlf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HLF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4hlf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HLF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=15Z:2-(3,4-DIHYDROXYPHENYL)-7-HYDROXY-4H-CHROMEN-4-ONE'>15Z</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=15Z:2-(3,4-DIHYDROXYPHENYL)-7-HYDROXY-4H-CHROMEN-4-ONE'>15Z</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3u9h|3u9h]], [[3u9y|3u9y]], [[3ua9|3ua9]], [[4hki|4hki]], [[4hkk|4hkk]], [[4hkn|4hkn]], [[4hl5|4hl5]], [[4hlg|4hlg]], [[4hlh|4hlh]], [[4hlk|4hlk]], [[4hlm|4hlm]], [[4hmh|4hmh]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3u9h|3u9h]], [[3u9y|3u9y]], [[3ua9|3ua9]], [[4hki|4hki]], [[4hkk|4hkk]], [[4hkn|4hkn]], [[4hl5|4hl5]], [[4hlg|4hlg]], [[4hlh|4hlh]], [[4hlk|4hlk]], [[4hlm|4hlm]], [[4hmh|4hmh]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TNKS2, PARP5B, TANK2, TNKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TNKS2, PARP5B, TANK2, TNKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hlf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hlf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hlf RCSB], [http://www.ebi.ac.uk/pdbsum/4hlf PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hlf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hlf OCA], [http://pdbe.org/4hlf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hlf RCSB], [http://www.ebi.ac.uk/pdbsum/4hlf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hlf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4hlf" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Human]]
[[Category: Haikarainen, T]]
[[Category: Haikarainen, T]]
[[Category: Lehtio, L]]
[[Category: Lehtio, L]]

Revision as of 06:02, 5 August 2016

Crystal structure of Tankyrase 2 in complex with 7,3',4'-Trihydroxyflavone

4hlf, resolution 2.15Å

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