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4lwf
From Proteopedia
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==Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ3== | ==Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ3== | ||
<StructureSection load='4lwf' size='340' side='right' caption='[[4lwf]], [[Resolution|resolution]] 1.75Å' scene=''> | <StructureSection load='4lwf' size='340' side='right' caption='[[4lwf]], [[Resolution|resolution]] 1.75Å' scene=''> | ||
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FJ3:4-(5-AMINO-1,2-OXAZOL-3-YL)-6-(PROPAN-2-YL)BENZENE-1,3-DIOL'>FJ3</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FJ3:4-(5-AMINO-1,2-OXAZOL-3-YL)-6-(PROPAN-2-YL)BENZENE-1,3-DIOL'>FJ3</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4lwe|4lwe]], [[4lwg|4lwg]], [[4lwh|4lwh]], [[4lwi|4lwi]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4lwe|4lwe]], [[4lwg|4lwg]], [[4lwh|4lwh]], [[4lwi|4lwi]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lwf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lwf RCSB], [http://www.ebi.ac.uk/pdbsum/4lwf PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lwf OCA], [http://pdbe.org/4lwf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lwf RCSB], [http://www.ebi.ac.uk/pdbsum/4lwf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lwf ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | [[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | ||
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| + | ==See Also== | ||
| + | *[[Heat Shock Proteins|Heat Shock Proteins]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 07:16, 5 August 2016
Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ3
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Categories: He, J | Li, J | Shi, F | Xiong, B | Atp binding | Chaperone | Molecularchaperone | Rossmann fold
