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3qiz

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==Crystal Structure of BoNT/A LC complexed with Hydroxamate-based Inhibitor PT-2==
==Crystal Structure of BoNT/A LC complexed with Hydroxamate-based Inhibitor PT-2==
<StructureSection load='3qiz' size='340' side='right' caption='[[3qiz]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3qiz' size='340' side='right' caption='[[3qiz]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3qiz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QIZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3qiz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clobh Clobh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QIZ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=QI2:(2S,4R)-2-(2-{[3-(4-FLUORO-3-METHYLPHENYL)PROPYL](METHYL)AMINO}ETHYL)-4-(4-FLUOROPHENYL)-N-HYDROXY-4-METHOXYBUTANAMIDE'>QI2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=QI2:(2S,4R)-2-(2-{[3-(4-FLUORO-3-METHYLPHENYL)PROPYL](METHYL)AMINO}ETHYL)-4-(4-FLUOROPHENYL)-N-HYDROXY-4-METHOXYBUTANAMIDE'>QI2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3qix|3qix]], [[3qiy|3qiy]], [[3qj0|3qj0]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3qix|3qix]], [[3qiy|3qiy]], [[3qj0|3qj0]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">botA, CBO0806, CLC_0862, Neurotoxin Light Chain ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1491 Clostridium botulinum])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">botA, CBO0806, CLC_0862, Neurotoxin Light Chain ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=441771 CLOBH])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qiz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qiz RCSB], [http://www.ebi.ac.uk/pdbsum/3qiz PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qiz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qiz OCA], [http://pdbe.org/3qiz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qiz RCSB], [http://www.ebi.ac.uk/pdbsum/3qiz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qiz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3qiz" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Botulinum neurotoxin|Botulinum neurotoxin]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Bontoxilysin]]
[[Category: Bontoxilysin]]
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[[Category: Clostridium botulinum]]
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[[Category: Clobh]]
[[Category: Han, G W]]
[[Category: Han, G W]]
[[Category: Stevens, R C]]
[[Category: Stevens, R C]]

Revision as of 07:35, 5 August 2016

Crystal Structure of BoNT/A LC complexed with Hydroxamate-based Inhibitor PT-2

3qiz, resolution 2.00Å

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