3zwy

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==Crystal structure of ADP-ribosyl cyclase complexed with 8-bromo-ADP- ribose and cyclic 8-bromo-cyclic-ADP-ribose==
==Crystal structure of ADP-ribosyl cyclase complexed with 8-bromo-ADP- ribose and cyclic 8-bromo-cyclic-ADP-ribose==
<StructureSection load='3zwy' size='340' side='right' caption='[[3zwy]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='3zwy' size='340' side='right' caption='[[3zwy]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3zwy]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZWY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3zwy]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZWY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AV1:[(2R,3S,4R,5R)-5-(6-AMINO-8-BROMO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+[(2R,3S,4S)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>AV1</scene>, <scene name='pdbligand=CV1:(2R,3R,4S,5R,13R,14S,15R,16R)-24-AMINO-18-BROMO-3,4,14,15-TETRAHYDROXY-7,9,11,25,26-PENTAOXA-17,19,22-TRIAZA-1-AZONIA-8,10-DIPHOSPHAPENTACYCLO[18.3.1.1^2,5^.1^13,16^.0^17,21^]HEXACOSA-1(24),18,20,22-TETRAENE-8,10-DIOLATE+8,10-DIOXIDE'>CV1</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AV1:[(2R,3S,4R,5R)-5-(6-AMINO-8-BROMO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+[(2R,3S,4S)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>AV1</scene>, <scene name='pdbligand=CV1:(2R,3R,4S,5R,13R,14S,15R,16R)-24-amino-18-bromo-3,4,14,15-tetrahydroxy-7,9,11,25,26-pentaoxa-17,19,22-triaza-1-azonia-8,10-diphosphapentacyclo[18.3.1.1^2,5^.1^13,16^.0^17,21^]hexacosa-1(24),18,20,22-tetraene-8,10-diolate+8,10-dioxide'>CV1</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1r0s|1r0s]], [[3zwn|3zwn]], [[1lbe|1lbe]], [[1r16|1r16]], [[3zwo|3zwo]], [[3zwp|3zwp]], [[1r12|1r12]], [[1r15|1r15]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1r0s|1r0s]], [[3zwn|3zwn]], [[1lbe|1lbe]], [[1r16|1r16]], [[3zwo|3zwo]], [[3zwp|3zwp]], [[1r12|1r12]], [[1r15|1r15]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zwy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zwy RCSB], [http://www.ebi.ac.uk/pdbsum/3zwy PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zwy OCA], [http://pdbe.org/3zwy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zwy RCSB], [http://www.ebi.ac.uk/pdbsum/3zwy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zwy ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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==See Also==
==See Also==
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*[[ADP-ribosyl cyclase|ADP-ribosyl cyclase]]
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*[[Cluster of Differentiation CD38|Cluster of Differentiation CD38]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aplysia californica]]
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[[Category: Aplca]]
[[Category: Graeff, R]]
[[Category: Graeff, R]]
[[Category: Hao, Q]]
[[Category: Hao, Q]]

Revision as of 16:15, 27 February 2019

Crystal structure of ADP-ribosyl cyclase complexed with 8-bromo-ADP- ribose and cyclic 8-bromo-cyclic-ADP-ribose

3zwy, resolution 2.40Å

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