2ax0
From Proteopedia
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|PDB= 2ax0 |SIZE=350|CAPTION= <scene name='initialview01'>2ax0</scene>, resolution 2.00Å | |PDB= 2ax0 |SIZE=350|CAPTION= <scene name='initialview01'>2ax0</scene>, resolution 2.00Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=5X:5R-(2E-METHYL-3-PHENYL-ALLYL)-3-(BENZENESULFONYLAMINO)-4-OXO-2-THIONOTHIAZOLIDINE'>5X</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ax0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ax0 OCA], [http://www.ebi.ac.uk/pdbsum/2ax0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ax0 RCSB]</span> | ||
}} | }} | ||
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[[Category: Wang, Z.]] | [[Category: Wang, Z.]] | ||
[[Category: Ye, Q.]] | [[Category: Ye, Q.]] | ||
| - | [[Category: 5X]] | ||
| - | [[Category: SO4]] | ||
[[Category: finger]] | [[Category: finger]] | ||
[[Category: hcv]] | [[Category: hcv]] | ||
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[[Category: thumb]] | [[Category: thumb]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:58:23 2008'' |
Revision as of 22:58, 30 March 2008
| |||||||
| , resolution 2.00Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Activity: | RNA-directed RNA polymerase, with EC number 2.7.7.48 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5x)
Overview
Novel non-nucleoside inhibitors of the HCV RNA polymerase (NS5b) with sub-micromolar biochemical potency have been identified which are selective for the inhibition of HCV NS5b over other polymerases. The structures of the complexes formed between several of these inhibitors and HCV NS5b were determined by X-ray crystallography, and the inhibitors were found to bind in an allosteric binding site separate from the active site. Structure-activity relationships and structural studies have identified the mechanism of action for compounds in this series, several of which possess drug-like properties, as unique, reversible, covalent inhibitors of HCV NS5b.
About this Structure
2AX0 is a Single protein structure of sequence from Hepatitis c virus. Full crystallographic information is available from OCA.
Reference
SAR and mode of action of novel non-nucleoside inhibitors of hepatitis C NS5b RNA polymerase., Powers JP, Piper DE, Li Y, Mayorga V, Anzola J, Chen JM, Jaen JC, Lee G, Liu J, Peterson MG, Tonn GR, Ye Q, Walker NP, Wang Z, J Med Chem. 2006 Feb 9;49(3):1034-46. PMID:16451069
Page seeded by OCA on Mon Mar 31 01:58:23 2008
Categories: Hepatitis c virus | RNA-directed RNA polymerase | Single protein | Anzola, J. | Chen, J M. | Jaen, J C. | Lee, G. | Li, Y. | Liu, J. | Mayorga, V. | Peterson, M G. | Piper, D E. | Powers, J P. | Tonn, G R. | Walker, N P. | Wang, Z. | Ye, Q. | Finger | Hcv | Ns5b | Palm | Polymerase | Thumb
