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2b0s

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|PDB= 2b0s |SIZE=350|CAPTION= <scene name='initialview01'>2b0s</scene>, resolution 2.30&Aring;
|PDB= 2b0s |SIZE=350|CAPTION= <scene name='initialview01'>2b0s</scene>, resolution 2.30&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene> and <scene name='pdbligand=ACY:ACETIC ACID'>ACY</scene>
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|LIGAND= <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
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|DOMAIN=
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|RELATEDENTRY=[[2b1a|2B1A]], [[2b1h|2B1H]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b0s OCA], [http://www.ebi.ac.uk/pdbsum/2b0s PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2b0s RCSB]</span>
}}
}}
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[[Category: Wilson, I A.]]
[[Category: Wilson, I A.]]
[[Category: Zolla-Pazner, S.]]
[[Category: Zolla-Pazner, S.]]
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[[Category: ACY]]
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[[Category: fab-peptide complex]]
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[[Category: EDO]]
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[[Category: gp120]]
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[[Category: fab-peptide complex; hiv-1; gp120; v3 loop]]
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[[Category: hiv-1]]
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[[Category: v3 loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:56:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:59:53 2008''

Revision as of 22:59, 30 March 2008

Image:2b0s.gif


PDB ID 2b0s

Drag the structure with the mouse to rotate
, resolution 2.30Å
Ligands: ,
Related: 2B1A, 2B1H


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal structure analysis of anti-HIV-1 V3 Fab 2219 in complex with MN peptide


Overview

Human monoclonal antibody 2219 is a neutralizing antibody isolated from a human immunodeficiency virus type 1-infected individual. 2219 was originally selected for binding to a V3 fusion protein and can neutralize primary isolates from subtypes B, A, and F. Thus, 2219 represents a cross-reactive, human anti-V3 antibody. Fab 2219 binds to one face of the variable V3 beta-hairpin, primarily contacting conserved residues on the N-terminal beta-strand of V3, leaving the V3 crown or tip largely accessible. Three V3/2219 complexes reveal the antibody-bound conformations for both the N- and C-terminal regions that flank the V3 crown and illustrate how twisting of the V3 loop alters the relative dispositions and pairing of the amino acids in the adjacent V3 beta-strands and how the antibody can accommodate V3 loops with different sequences.

About this Structure

2B0S is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structures of human immunodeficiency virus type 1 (HIV-1) neutralizing antibody 2219 in complex with three different V3 peptides reveal a new binding mode for HIV-1 cross-reactivity., Stanfield RL, Gorny MK, Zolla-Pazner S, Wilson IA, J Virol. 2006 Jun;80(12):6093-105. PMID:16731948

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