2b5m

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|ACTIVITY=
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|RELATEDENTRY=[[2b5l|2B5L]], [[2b5n|2B5N]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b5m OCA], [http://www.ebi.ac.uk/pdbsum/2b5m PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2b5m RCSB]</span>
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[[Category: propeller cluster]]
[[Category: propeller cluster]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:01:47 2008''

Revision as of 23:01, 30 March 2008

Image:2b5m.gif


PDB ID 2b5m

Drag the structure with the mouse to rotate
, resolution 2.92Å
Related: 2B5L, 2B5N


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of DDB1


Overview

The DDB1-Cul4A ubiquitin ligase complex promotes protein ubiquitination in diverse cellular functions and is reprogrammed by the V proteins of paramyxoviruses to degrade STATs and block interferon signaling. Here we report the crystal structures of DDB1 alone and in complex with the simian virus 5 V protein. The DDB1 structure reveals an intertwined three-propeller cluster, which contains two tightly coupled beta propellers with a large pocket in between and a third beta propeller flexibly attached on the side. The rigid double-propeller fold of DDB1 is targeted by the viral V protein, which inserts an entire helix into the double-propeller pocket, whereas the third propeller domain docks DDB1 to the N terminus of the Cul4A scaffold. Together, these results not only provide structural insights into how the virus hijacks the DDB1-Cul4A ubiquitin ligase but also establish a structural framework for understanding the multiple functions of DDB1 in the uniquely assembled cullin-RING E3 machinery.

About this Structure

2B5M is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase., Li T, Chen X, Garbutt KC, Zhou P, Zheng N, Cell. 2006 Jan 13;124(1):105-17. PMID:16413485

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