2k50
From Proteopedia
(Difference between revisions)
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<StructureSection load='2k50' size='340' side='right' caption='[[2k50]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='2k50' size='340' side='right' caption='[[2k50]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2k50]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2k50]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Metth Metth]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K50 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K50 FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MTH1385, MTH_1385 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=187420 | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MTH1385, MTH_1385 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=187420 METTH])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k50 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2k50 RCSB], [http://www.ebi.ac.uk/pdbsum/2k50 PDBsum], [http://www.topsan.org/Proteins/NESGC/2k50 TOPSAN]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k50 OCA], [http://pdbe.org/2k50 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2k50 RCSB], [http://www.ebi.ac.uk/pdbsum/2k50 PDBsum], [http://www.topsan.org/Proteins/NESGC/2k50 TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/ | + | [[http://www.uniprot.org/uniprot/RPA_METTH RPA_METTH]] Inhibits DNA polymerase activity of PolB, which can be overcome by RFC and PNCA. Stimulates 3'-to 5'-exonuclease activity of PolB at 30 degrees Celsius, but has no effect at 50 or 70 degrees Celsius. Bind ssDNA and replication forks; replication forks structures bind both Hel308 and this protein. Has no effect on helicase activity of Hel308; may help target the helicase to DNA substrates that require DNA re-modeling.<ref>PMID:10497247</ref> <ref>PMID:21195035</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Metth]] |
[[Category: Acton, T B]] | [[Category: Acton, T B]] | ||
[[Category: Ciccosanti, C]] | [[Category: Ciccosanti, C]] | ||
Revision as of 16:30, 10 September 2015
Solution NMR Structure of the replication Factor A Related Protein from Methanobacterium thermoautotrophicum. Northeast Structural Genomics Target TR91A.
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