2b6p

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|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
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|DOMAIN=
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|RELATEDENTRY=[[1sor|1SOR]], [[2b6o|2B6O]], [[1ymg|1YMG]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b6p OCA], [http://www.ebi.ac.uk/pdbsum/2b6p PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2b6p RCSB]</span>
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[[Category: Sliz, P.]]
[[Category: Sliz, P.]]
[[Category: Walz, T.]]
[[Category: Walz, T.]]
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[[Category: aquaporin-0; aqp0; lens mip; open water pore; aquaporin; membrane protein;]]
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[[Category: aqp0]]
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[[Category: aquaporin]]
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[[Category: aquaporin-0]]
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[[Category: lens mip]]
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[[Category: membrane protein;]]
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[[Category: open water pore]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:58:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:02:15 2008''

Revision as of 23:02, 30 March 2008

Image:2b6p.gif


PDB ID 2b6p

Drag the structure with the mouse to rotate
, resolution 2.40Å
Related: 1SOR, 2B6O, 1YMG


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



X-ray structure of lens Aquaporin-0 (AQP0) (lens MIP) in an open pore state


Overview

Lens-specific aquaporin-0 (AQP0) functions as a specific water pore and forms the thin junctions between fibre cells. Here we describe a 1.9 A resolution structure of junctional AQP0, determined by electron crystallography of double-layered two-dimensional crystals. Comparison of junctional and non-junctional AQP0 structures shows that junction formation depends on a conformational switch in an extracellular loop, which may result from cleavage of the cytoplasmic amino and carboxy termini. In the centre of the water pathway, the closed pore in junctional AQP0 retains only three water molecules, which are too widely spaced to form hydrogen bonds with each other. Packing interactions between AQP0 tetramers in the crystalline array are mediated by lipid molecules, which assume preferred conformations. We were therefore able to build an atomic model for the lipid bilayer surrounding the AQP0 tetramers, and we describe lipid-protein interactions.

About this Structure

2B6P is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Lipid-protein interactions in double-layered two-dimensional AQP0 crystals., Gonen T, Cheng Y, Sliz P, Hiroaki Y, Fujiyoshi Y, Harrison SC, Walz T, Nature. 2005 Dec 1;438(7068):633-8. PMID:16319884

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