1ast
From Proteopedia
(Difference between revisions)
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<StructureSection load='1ast' size='340' side='right' caption='[[1ast]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='1ast' size='340' side='right' caption='[[1ast]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1ast]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1ast]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Astas Astas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AST OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AST FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Astacin Astacin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.21 3.4.24.21] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Astacin Astacin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.21 3.4.24.21] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ast FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ast OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ast RCSB], [http://www.ebi.ac.uk/pdbsum/1ast PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ast FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ast OCA], [http://pdbe.org/1ast PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ast RCSB], [http://www.ebi.ac.uk/pdbsum/1ast PDBsum]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/ | + | [[http://www.uniprot.org/uniprot/ASTA_ASTAS ASTA_ASTAS]] This protease prefers to cleave in front of small aliphatic residues (P1'). The presence of Lys or Arg in the P1 and P2 position yields high-turnover substrates. In the P3 position the enzyme prefers Pro > Val > Leu > Ala > Gly. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 1ast" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Astacin]] | [[Category: Astacin]] | ||
| - | [[Category: | + | [[Category: Astas]] |
[[Category: Bode, W]] | [[Category: Bode, W]] | ||
[[Category: Gomis-Rueth, F X]] | [[Category: Gomis-Rueth, F X]] | ||
[[Category: Stoecker, W]] | [[Category: Stoecker, W]] | ||
Revision as of 16:50, 10 September 2015
STRUCTURE OF ASTACIN AND IMPLICATIONS FOR ACTIVATION OF ASTACINS AND ZINC-LIGATION OF COLLAGENASES
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Categories: Astacin | Astas | Bode, W | Gomis-Rueth, F X | Stoecker, W
