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4dhu

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==Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening==
==Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening==
<StructureSection load='4dhu' size='340' side='right' caption='[[4dhu]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
<StructureSection load='4dhu' size='340' side='right' caption='[[4dhu]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4dhu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DHU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DHU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4dhu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DHU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DHU FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0KH:(2-{2-[(2,3-DICHLOROPHENYL)AMINO]-2-OXOETHOXY}PHENYL)PHOSPHONIC+ACID'>0KH</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0KH:(2-{2-[(2,3-DICHLOROPHENYL)AMINO]-2-OXOETHOXY}PHENYL)PHOSPHONIC+ACID'>0KH</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3t0l|3t0l]], [[3t0m|3t0m]], [[3u9x|3u9x]], [[4dhm|4dhm]], [[4dhn|4dhn]], [[4dho|4dho]], [[4dhp|4dhp]], [[4dhq|4dhq]], [[4dhr|4dhr]], [[4dhs|4dhs]], [[4dht|4dht]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3t0l|3t0l]], [[3t0m|3t0m]], [[3u9x|3u9x]], [[4dhm|4dhm]], [[4dhn|4dhn]], [[4dho|4dho]], [[4dhp|4dhp]], [[4dhq|4dhq]], [[4dhr|4dhr]], [[4dhs|4dhs]], [[4dht|4dht]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HME1, SFN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HME1, SFN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dhu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dhu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dhu RCSB], [http://www.ebi.ac.uk/pdbsum/4dhu PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dhu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dhu OCA], [http://pdbe.org/4dhu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dhu RCSB], [http://www.ebi.ac.uk/pdbsum/4dhu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dhu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4dhu" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Human]]
[[Category: Kohlbacher, O]]
[[Category: Kohlbacher, O]]
[[Category: Ottmann, C]]
[[Category: Ottmann, C]]

Revision as of 19:27, 5 August 2016

Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening

4dhu, resolution 1.67Å

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