2br7
From Proteopedia
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|PDB= 2br7 |SIZE=350|CAPTION= <scene name='initialview01'>2br7</scene>, resolution 3.00Å | |PDB= 2br7 |SIZE=350|CAPTION= <scene name='initialview01'>2br7</scene>, resolution 3.00Å | ||
|SITE= <scene name='pdbsite=AC1:Epe+Binding+Site+For+Chain+D'>AC1</scene> | |SITE= <scene name='pdbsite=AC1:Epe+Binding+Site+For+Chain+D'>AC1</scene> | ||
| - | |LIGAND= <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID'>EPE</scene> | + | |LIGAND= <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2br7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2br7 OCA], [http://www.ebi.ac.uk/pdbsum/2br7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2br7 RCSB]</span> | ||
}} | }} | ||
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[[Category: Tsetlin, V.]] | [[Category: Tsetlin, V.]] | ||
[[Category: Zhmak, M N.]] | [[Category: Zhmak, M N.]] | ||
| - | [[Category: EPE]] | ||
[[Category: 3d-structure]] | [[Category: 3d-structure]] | ||
[[Category: glycoprotein]] | [[Category: glycoprotein]] | ||
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[[Category: signal]] | [[Category: signal]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:10:31 2008'' |
Revision as of 23:10, 30 March 2008
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| , resolution 3.00Å | |||||||
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| Sites: | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF ACETYLCHOLINE-BINDING PROTEIN (ACHBP) FROM APLYSIA CALIFORNICA IN COMPLEX WITH HEPES
Overview
Conotoxins (Ctx) form a large family of peptide toxins from cone snail venoms that act on a broad spectrum of ion channels and receptors. The subgroup alpha-Ctx specifically and selectively binds to subtypes of nicotinic acetylcholine receptors (nAChRs), which are targets for treatment of several neurological disorders. Here we present the structure at a resolution of 2.4 A of alpha-Ctx PnIA (A10L D14K), a potent blocker of the alpha(7)-nAChR, bound with high affinity to acetylcholine binding protein (AChBP), the prototype for the ligand-binding domains of the nAChR superfamily. Alpha-Ctx is buried deep within the ligand-binding site and interacts with residues on both faces of adjacent subunits. The toxin itself does not change conformation, but displaces the C loop of AChBP and induces a rigid-body subunit movement. Knowledge of these contacts could facilitate the rational design of drug leads using the Ctx framework and may lead to compounds with increased receptor subtype selectivity.
About this Structure
2BR7 is a Single protein structure of sequence from Aplysia californica. Full crystallographic information is available from OCA.
Reference
Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant., Celie PH, Kasheverov IE, Mordvintsev DY, Hogg RC, van Nierop P, van Elk R, van Rossum-Fikkert SE, Zhmak MN, Bertrand D, Tsetlin V, Sixma TK, Smit AB, Nat Struct Mol Biol. 2005 Jul;12(7):582-8. Epub 2005 Jun 12. PMID:15951818
Page seeded by OCA on Mon Mar 31 02:10:31 2008
Categories: Aplysia californica | Single protein | Bertrand, D. | Celie, P H.N. | Elk, R Van. | Hogg, R C. | Kasheverov, I E. | Mordvintsev, D Y. | Nierop, P Van. | Rossum-Fikkert, S E.Van. | Sixma, T K. | Smit, A B. | Tsetlin, V. | Zhmak, M N. | 3d-structure | Glycoprotein | Igg-fold | Immunoglobulin domain | Nicotinic receptor | Pentamer | Receptor protein | Signal
