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| - | ==Crystal structure of insulin degrading enzyme in complex with macrophage inflammatory protein 1 beta==
| + | #REDIRECT [[4ral]] This PDB entry is obsolete and replaced by 4ral |
| - | <StructureSection load='4qld' size='340' side='right' caption='[[4qld]], [[Resolution|resolution]] 3.19Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[4qld]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QLD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QLD FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Insulysin Insulysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.56 3.4.24.56] </span></td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qld OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qld RCSB], [http://www.ebi.ac.uk/pdbsum/4qld PDBsum]</span></td></tr>
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| - | </table>
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> [[http://www.uniprot.org/uniprot/CCL4_HUMAN CCL4_HUMAN]] Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.<ref>PMID:8525373</ref> <ref>PMID:10540332</ref> <ref>PMID:12070155</ref>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Insulysin]]
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| - | [[Category: Guo, Q]]
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| - | [[Category: Liang, W]]
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| - | [[Category: Ren, M]]
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| - | [[Category: Tang, W J]]
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| - | [[Category: Chemotaxis]]
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| - | [[Category: Disulfide bond]]
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| - | [[Category: Hydrolase-cytokine complex]]
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| - | [[Category: Ide]]
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| - | [[Category: Inflammatory response]]
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| - | [[Category: Metal-binding]]
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| - | [[Category: Metalloprotease]]
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| - | [[Category: Mip1alpha]]
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| - | [[Category: Protease]]
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| - | [[Category: Secreted]]
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