4mhi
From Proteopedia
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==Crystal structure of a H5N1 influenza virus hemagglutinin from A/goose/Guangdong/1/96== | ==Crystal structure of a H5N1 influenza virus hemagglutinin from A/goose/Guangdong/1/96== | ||
<StructureSection load='4mhi' size='340' side='right' caption='[[4mhi]], [[Resolution|resolution]] 2.59Å' scene=''> | <StructureSection load='4mhi' size='340' side='right' caption='[[4mhi]], [[Resolution|resolution]] 2.59Å' scene=''> | ||
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mhh|4mhh]], [[4mhj|4mhj]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mhh|4mhh]], [[4mhj|4mhj]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93838 I96A0])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93838 I96A0])</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mhi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mhi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mhi RCSB], [http://www.ebi.ac.uk/pdbsum/4mhi PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mhi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mhi OCA], [http://pdbe.org/4mhi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mhi RCSB], [http://www.ebi.ac.uk/pdbsum/4mhi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mhi ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | {{Large structure}} | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/HEMA_I96A0 HEMA_I96A0]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity). | [[http://www.uniprot.org/uniprot/HEMA_I96A0 HEMA_I96A0]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity). | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 4mhi" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
Revision as of 23:26, 5 August 2016
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Crystal structure of a H5N1 influenza virus hemagglutinin from A/goose/Guangdong/1/96
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