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2ykc

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Revision as of 10:07, 4 August 2016

TRICYCLIC SERIES OF HSP90 INHIBITORS

Structural highlights

2ykc is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Related:	2yi0, 2yk9, 2bsm, 1osf, 2wi3, 2ye4, 2yi5, 2ye5, 2bz5, 2yei, 2ccs, 2yeg, 1uyf, 1yc3, 1uyi, 2byi, 2ye3, 2yi6, 2vci, 2wi1, 2xjx, 2fwz, 2xdk, 1uyh, 2xjg, 2fwy, 1uyl, 1uye, 2xab, 2yeh, 2xhr, 2xht, 1uy7, 2yef, 2byh, 2wi5, 1uy9, 1yes, 2cdd, 1byq, 2yi7, 1uy8, 2wi4, 2bug, 2ye7, 2yeb, 2uwd, 2wi7, 2xhx, 2bt0, 2yej, 1yer, 2xdu, 2yec, 1uyg, 2ccu, 2xds, 2xdx, 2xk2, 2xjj, 1uyd, 2wi2, 2xdl, 1uy6, 2yee, 2ye2, 2vcj, 1yc4, 2ye9, 2c2l, 1uyk, 2cct, 2yk2, 2wi6, 1yc1, 2yea, 2ye6, 2yed, 1uyc, 1yet, 2yjx, 2jjc, 2ye8, 2yke, 2ykb
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.^[1] ^[2]

Publication Abstract from PubMed

A novel class of heat shock protein 90 (Hsp90) inhibitors was developed after a low throughput screen (LTS) of a focused library containing approximately 21K compounds selected by virtual screening. The initial [1-{3-H-imidazo[4-5-c]pyridin-2-yl}-3,4-dihydro-2H-pyrido[2,1-a]isoindole- 6-one] (1) compound showed moderate activity (IC(50) = 7.6 muM on Hsp82, the yeast homologue of Hsp90). A high-resolution X-ray structure shows that compound 1 binds into an "induced" hydrophobic pocket, 10-15 A away from the ATP/resorcinol binding site. Iterative cycles of structure-based drug design (SBDD) and chemical synthesis led to the design and preparation of analogues with improved affinity. These optimized molecules make productive interactions within the ATP binding site as reported by other Hsp90 inhibitors. This resulted in compound 8, which is a highly potent inhibitor in biochemical and cellular assays (K(d) = 0.35 nM on Hsp90; IC(50) = 30 nM on SKBr3 mammary carcinoma cells) and in an in vivo leukemia model.

Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-c]pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone.,Vallee F, Carrez C, Pilorge F, Dupuy A, Parent A, Bertin L, Thompson F, Ferrari P, Fassy F, Lamberton A, Thomas A, Arrebola R, Guerif S, Rohaut A, Certal V, Ruxer JM, Delorme C, Jouanen A, Dumas J, Grepin C, Combeau C, Goulaouic H, Dereu N, Mikol V, Mailliet P, Minoux H J Med Chem. 2011 Oct 27;54(20):7206-19. Epub 2011 Oct 5. PMID:21972823^[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Martinez-Ruiz A, Villanueva L, Gonzalez de Orduna C, Lopez-Ferrer D, Higueras MA, Tarin C, Rodriguez-Crespo I, Vazquez J, Lamas S. S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities. Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8525-30. Epub 2005 Jun 3. PMID:15937123 doi:10.1073/pnas.0407294102
↑ Forsythe HL, Jarvis JL, Turner JW, Elmore LW, Holt SE. Stable association of hsp90 and p23, but Not hsp70, with active human telomerase. J Biol Chem. 2001 May 11;276(19):15571-4. Epub 2001 Mar 23. PMID:11274138 doi:10.1074/jbc.C100055200
↑ Vallee F, Carrez C, Pilorge F, Dupuy A, Parent A, Bertin L, Thompson F, Ferrari P, Fassy F, Lamberton A, Thomas A, Arrebola R, Guerif S, Rohaut A, Certal V, Ruxer JM, Delorme C, Jouanen A, Dumas J, Grepin C, Combeau C, Goulaouic H, Dereu N, Mikol V, Mailliet P, Minoux H. Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-c]pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone. J Med Chem. 2011 Oct 27;54(20):7206-19. Epub 2011 Oct 5. PMID:21972823 doi:10.1021/jm200784m

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ykc"

Categories: Human | Dupuy, A | Vallee, F | Chaperone | Inhibition

@@ Line 1: / Line 1: @@
 ==TRICYCLIC SERIES OF HSP90 INHIBITORS==
 <StructureSection load='2ykc' size='340' side='right' caption='[[2ykc]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2ykc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YKC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YKC FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2ykc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YKC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YKC FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=YKC:N-[4-(3H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-9H-FLUOREN-9-YL-ISONICOTINAMIDE'>YKC</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yi0|2yi0]], [[2yk9|2yk9]], [[2bsm|2bsm]], [[1osf|1osf]], [[2wi3|2wi3]], [[2ye4|2ye4]], [[2yi5|2yi5]], [[2ye5|2ye5]], [[2bz5|2bz5]], [[2yei|2yei]], [[2ccs|2ccs]], [[2yeg|2yeg]], [[1uyf|1uyf]], [[1yc3|1yc3]], [[1uyi|1uyi]], [[2byi|2byi]], [[2ye3|2ye3]], [[2yi6|2yi6]], [[2vci|2vci]], [[2wi1|2wi1]], [[2xjx|2xjx]], [[2fwz|2fwz]], [[2xdk|2xdk]], [[1uyh|1uyh]], [[2xjg|2xjg]], [[2fwy|2fwy]], [[1uyl|1uyl]], [[1uye|1uye]], [[2xab|2xab]], [[2yeh|2yeh]], [[2xhr|2xhr]], [[2xht|2xht]], [[1uy7|1uy7]], [[2yef|2yef]], [[2byh|2byh]], [[2wi5|2wi5]], [[1uy9|1uy9]], [[1yes|1yes]], [[2cdd|2cdd]], [[1byq|1byq]], [[2yi7|2yi7]], [[1uy8|1uy8]], [[2wi4|2wi4]], [[2bug|2bug]], [[2ye7|2ye7]], [[2yeb|2yeb]], [[2uwd|2uwd]], [[2wi7|2wi7]], [[2xhx|2xhx]], [[2bt0|2bt0]], [[2yej|2yej]], [[1yer|1yer]], [[2xdu|2xdu]], [[2yec|2yec]], [[1uyg|1uyg]], [[2ccu|2ccu]], [[2xds|2xds]], [[2xdx|2xdx]], [[2xk2|2xk2]], [[2xjj|2xjj]], [[1uyd|1uyd]], [[2wi2|2wi2]], [[2xdl|2xdl]], [[1uy6|1uy6]], [[2yee|2yee]], [[2ye2|2ye2]], [[2vcj|2vcj]], [[1yc4|1yc4]], [[2ye9|2ye9]], [[2c2l|2c2l]], [[1uyk|1uyk]], [[2cct|2cct]], [[2yk2|2yk2]], [[2wi6|2wi6]], [[1yc1|1yc1]], [[2yea|2yea]], [[2ye6|2ye6]], [[2yed|2yed]], [[1uyc|1uyc]], [[1yet|1yet]], [[2yjx|2yjx]], [[2jjc|2jjc]], [[2ye8|2ye8]], [[2yke|2yke]], [[2ykb|2ykb]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ykc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ykc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ykc RCSB], [http://www.ebi.ac.uk/pdbsum/2ykc PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ykc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ykc OCA], [http://pdbe.org/2ykc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ykc RCSB], [http://www.ebi.ac.uk/pdbsum/2ykc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ykc ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 17: / Line 18: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 2ykc" style="background-color:#fffaf0;"></div>
 ==See Also==
@@ Line 24: / Line 26: @@
 __TOC__
 </StructureSection>
-[[Category: Homo sapiens]]
+[[Category: Human]]
 [[Category: Dupuy, A]]
 [[Category: Vallee, F]]
 [[Category: Chaperone]]
 [[Category: Inhibition]]

2ykc

From Proteopedia

Revision as of 10:07, 4 August 2016

TRICYCLIC SERIES OF HSP90 INHIBITORS

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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