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3p6a

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==Crystal Structure of the DH/PH domains of p115-RhoGEF (R399E mutant)==
==Crystal Structure of the DH/PH domains of p115-RhoGEF (R399E mutant)==
<StructureSection load='3p6a' size='340' side='right' caption='[[3p6a]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='3p6a' size='340' side='right' caption='[[3p6a]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3p6a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P6A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P6A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3p6a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P6A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P6A FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3odo|3odo]], [[3odw|3odw]], [[3odx|3odx]], [[1x86|1x86]], [[1txd|1txd]], [[1xcg|1xcg]]</td></tr>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3odo|3odo]], [[3odw|3odw]], [[3odx|3odx]], [[1x86|1x86]], [[1txd|1txd]], [[1xcg|1xcg]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ARHGEF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ARHGEF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p6a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p6a RCSB], [http://www.ebi.ac.uk/pdbsum/3p6a PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p6a OCA], [http://pdbe.org/3p6a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3p6a RCSB], [http://www.ebi.ac.uk/pdbsum/3p6a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3p6a ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ARHG1_HUMAN ARHG1_HUMAN]] Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.<ref>PMID:8810315</ref> <ref>PMID:9641915</ref> <ref>PMID:9641916</ref> <ref>PMID:20098430</ref>
[[http://www.uniprot.org/uniprot/ARHG1_HUMAN ARHG1_HUMAN]] Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.<ref>PMID:8810315</ref> <ref>PMID:9641915</ref> <ref>PMID:9641916</ref> <ref>PMID:20098430</ref>
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==See Also==
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*[[Rho guanine nucleotide exchange factor|Rho guanine nucleotide exchange factor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Human]]
[[Category: Chen, Z]]
[[Category: Chen, Z]]
[[Category: Guo, L]]
[[Category: Guo, L]]

Revision as of 14:07, 4 August 2016

Crystal Structure of the DH/PH domains of p115-RhoGEF (R399E mutant)

3p6a, resolution 2.50Å

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