1fyg
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1fyg]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FYG FirstGlance]. <br> | <table><tr><td colspan='2'>[[1fyg]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FYG FirstGlance]. <br> | ||
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fyg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fyg RCSB], [http://www.ebi.ac.uk/pdbsum/1fyg PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fyg OCA], [http://pdbe.org/1fyg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1fyg RCSB], [http://www.ebi.ac.uk/pdbsum/1fyg PDBsum]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/ | + | [[http://www.uniprot.org/uniprot/CO13_CONST CO13_CONST]] Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This peptide selectively targets N-type voltage-gated calcium channels (Cav2.2/CACNA1B). Displays an analgesic potency similar to MVIIA in a range of acute and chronic pain models in rodents, but has less adverse effects compared with identical dosages of MVIIA injected intrathecally.<ref>PMID:15880145</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 04:12, 11 September 2015
Solution structure of omega conotoxin SO3 determined by 1H-NMR
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Categories: Yan, Y | Zhang, R | Beta sheet | Toxin
