2d3t
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 2d3t |SIZE=350|CAPTION= <scene name='initialview01'>2d3t</scene>, resolution 3.4Å | |PDB= 2d3t |SIZE=350|CAPTION= <scene name='initialview01'>2d3t</scene>, resolution 3.4Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene> | + | |LIGAND= <scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Acetyl-CoA_C-acyltransferase Acetyl-CoA C-acyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.16 2.3.1.16] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetyl-CoA_C-acyltransferase Acetyl-CoA C-acyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.16 2.3.1.16] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1wdk|1WDK]], [[1wdl|1WDL]], [[1wdm|1WDM]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2d3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d3t OCA], [http://www.ebi.ac.uk/pdbsum/2d3t PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2d3t RCSB]</span> | ||
}} | }} | ||
| Line 28: | Line 31: | ||
[[Category: Suzuki, Y.]] | [[Category: Suzuki, Y.]] | ||
[[Category: Tsuchiya, D.]] | [[Category: Tsuchiya, D.]] | ||
| - | [[Category: ACO]] | ||
| - | [[Category: NAD]] | ||
[[Category: alpha2beta2 heterotetrameric complex]] | [[Category: alpha2beta2 heterotetrameric complex]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:29:56 2008'' |
Revision as of 23:29, 30 March 2008
| |||||||
| , resolution 3.4Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Activity: | Acetyl-CoA C-acyltransferase, with EC number 2.3.1.16 | ||||||
| Related: | 1WDK, 1WDL, 1WDM
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Fatty Acid beta-oxidation multienzyme complex from Pseudomonas Fragi, Form V
Overview
The quaternary structure of a fatty acid beta-oxidation multienzyme complex, catalyzing three sequential reactions, was investigated by X-ray crystallographic and small-angle X-ray solution scattering analyses. X-ray crystallography revealed an intermediate structure of the complex among the previously reported structures. However, the theoretical scattering curves calculated from the crystal structures remarkably disagree with the experimental profiles. Instead, an ensemble of the atomic models, which were all calculated by rigid-body optimization, reasonably explained the experimental data. These structures significantly differ from those in the crystals, but they maintain the substrate binding pocket at the domain boundary. Comparisons among these structures indicated that binding of 3-hydroxyhexadecanoyl-CoA or nicotinamide adenine dinucleotide induces domain rearrangements in the complex. The conformational changes suggest the structural events occurring during the chain reaction catalyzed by the multienzyme complex.
About this Structure
2D3T is a Protein complex structure of sequences from Pseudomonas fragi. Full crystallographic information is available from OCA.
Reference
Ligand-induced domain rearrangement of fatty acid beta-oxidation multienzyme complex., Tsuchiya D, Shimizu N, Ishikawa M, Suzuki Y, Morikawa K, Structure. 2006 Feb;14(2):237-46. PMID:16472743
Page seeded by OCA on Mon Mar 31 02:29:56 2008
