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1n4y

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Revision as of 05:40, 11 September 2015

REFINED STRUCTURE OF KISTRIN

Structural highlights

1n4y is a 1 chain structure with sequence from Agkistrodon rhodostoma. This structure supersedes the now removed PDB entry 1kst. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	1kst
Gene:	RHOD (Agkistrodon rhodostoma)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[VM2RH_CALRH] Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity). Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The structure of kistrin, which is a member of a homologous family of glycoprotein IIb-IIIa (GP IIb-IIIa) antagonists and potent protein inhibitors of platelet aggregation, has been determined by two-dimensional nuclear magnetic resonance (NMR) spectroscopy. The 68-residue protein consists of a series of tightly packed loops held together by six disulfide bonds and has almost no regular secondary structure. Kistrin has an Arg-Gly-Asp (RGD) adhesion site recognition sequence important for binding to GP IIb-IIIa that is located at the apex of a long loop across the surface of the protein.

Solution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist.,Adler M, Lazarus RA, Dennis MS, Wagner G Science. 1991 Jul 26;253(5018):445-8. PMID:1862345^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Adler M, Lazarus RA, Dennis MS, Wagner G. Solution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist. Science. 1991 Jul 26;253(5018):445-8. PMID:1862345

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1n4y"

@@ Line 2: / Line 2: @@
 <StructureSection load='1n4y' size='340' side='right' caption='[[1n4y]], [[NMR_Ensembles_of_Models | 18 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1n4y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1kst 1kst]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N4Y FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1n4y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Agkistrodon_rhodostoma Agkistrodon rhodostoma]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1kst 1kst]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N4Y FirstGlance]. <br>
 </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1kst|1kst]]</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RHOD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8717 Calloselasma rhodostoma])</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RHOD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8717 Agkistrodon rhodostoma])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1n4y RCSB], [http://www.ebi.ac.uk/pdbsum/1n4y PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4y OCA], [http://pdbe.org/1n4y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1n4y RCSB], [http://www.ebi.ac.uk/pdbsum/1n4y PDBsum]</span></td></tr>
 </table>
 == Function ==
@@ Line 27: / Line 27: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 1n4y" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Disintegrin|Disintegrin]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Calloselasma rhodostoma]]
+[[Category: Agkistrodon rhodostoma]]
 [[Category: Dennis, M S]]
 [[Category: Krane, J]]

1n4y

From Proteopedia

Revision as of 05:40, 11 September 2015

REFINED STRUCTURE OF KISTRIN

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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