2ddu
From Proteopedia
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|PDB= 2ddu |SIZE=350|CAPTION= <scene name='initialview01'>2ddu</scene>, resolution 2.05Å | |PDB= 2ddu |SIZE=350|CAPTION= <scene name='initialview01'>2ddu</scene>, resolution 2.05Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> | + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ddu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ddu OCA], [http://www.ebi.ac.uk/pdbsum/2ddu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ddu RCSB]</span> | ||
}} | }} | ||
| Line 25: | Line 28: | ||
[[Category: Takagi, J.]] | [[Category: Takagi, J.]] | ||
[[Category: Yasui, N.]] | [[Category: Yasui, N.]] | ||
| - | [[Category: CA]] | ||
| - | [[Category: CL]] | ||
| - | [[Category: MG]] | ||
[[Category: beta-jelly-roll]] | [[Category: beta-jelly-roll]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:33:22 2008'' |
Revision as of 23:33, 30 March 2008
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| , resolution 2.05Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the third repeat domain of reelin
Overview
The large extracellular glycoprotein reelin directs neuronal migration during brain development and plays a fundamental role in layer formation. It is composed of eight tandem repeats of an approximately 380-residue unit, termed the reelin repeat, which has a central epidermal growth factor (EGF) module flanked by two homologous subrepeats with no obvious sequence similarity to proteins of known structure. The 2.05 A crystal structure of the mouse reelin repeat 3 reveals that the subrepeat assumes a beta-jelly-roll fold with unexpected structural similarity to carbohydrate-binding domains. Despite the interruption by the EGF module, the two subdomains make direct contact, resulting in a compact overall structure. Electron micrographs of a four-domain fragment encompassing repeats 3-6, which is capable of inducing Disabled-1 phosphorylation in neurons, show a rod-like shape. Furthermore, a three-dimensional molecular envelope of the fragment obtained by single-particle tomography can be fitted with four concatenated repeat 3 atomic structures, providing the first glimpse of the structural unit for this important signaling molecule.
About this Structure
2DDU is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structure of a signaling-competent reelin fragment revealed by X-ray crystallography and electron tomography., Nogi T, Yasui N, Hattori M, Iwasaki K, Takagi J, EMBO J. 2006 Aug 9;25(15):3675-83. Epub 2006 Jul 20. PMID:16858396
Page seeded by OCA on Mon Mar 31 02:33:22 2008
