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4a2j

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==PR X-Ray structures in agonist conformations reveal two different mechanisms for partial agonism in 11beta-substituted steroids==
==PR X-Ray structures in agonist conformations reveal two different mechanisms for partial agonism in 11beta-substituted steroids==
<StructureSection load='4a2j' size='340' side='right' caption='[[4a2j]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='4a2j' size='340' side='right' caption='[[4a2j]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4a2j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A2J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A2J FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4a2j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A2J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A2J FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AS0:4-[(11BETA,17BETA)-17-METHOXY-17-(METHOXYMETHYL)-3-OXOESTRA-4,9-DIEN-11-YL]BENZALDEHYDE+OXIME'>AS0</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AS0:4-[(11BETA,17BETA)-17-METHOXY-17-(METHOXYMETHYL)-3-OXOESTRA-4,9-DIEN-11-YL]BENZALDEHYDE+OXIME'>AS0</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2c7a|2c7a]], [[2w8y|2w8y]], [[3zr7|3zr7]], [[1e3k|1e3k]], [[3zra|3zra]], [[3zrb|3zrb]], [[1a28|1a28]], [[1sqn|1sqn]], [[1zuc|1zuc]], [[1sr7|1sr7]], [[4a2k|4a2k]], [[4apu|4apu]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2c7a|2c7a]], [[2w8y|2w8y]], [[3zr7|3zr7]], [[1e3k|1e3k]], [[3zra|3zra]], [[3zrb|3zrb]], [[1a28|1a28]], [[1sqn|1sqn]], [[1zuc|1zuc]], [[1sr7|1sr7]], [[4a2k|4a2k]], [[4apu|4apu]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a2j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a2j RCSB], [http://www.ebi.ac.uk/pdbsum/4a2j PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a2j OCA], [http://pdbe.org/4a2j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4a2j RCSB], [http://www.ebi.ac.uk/pdbsum/4a2j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4a2j ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4a2j" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Human]]
[[Category: Bosch, R]]
[[Category: Bosch, R]]
[[Category: Lusher, S J]]
[[Category: Lusher, S J]]

Revision as of 22:52, 4 August 2016

PR X-Ray structures in agonist conformations reveal two different mechanisms for partial agonism in 11beta-substituted steroids

4a2j, resolution 2.00Å

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