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2dpk
From Proteopedia
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|PDB= 2dpk |SIZE=350|CAPTION= <scene name='initialview01'>2dpk</scene>, resolution 2.50Å | |PDB= 2dpk |SIZE=350|CAPTION= <scene name='initialview01'>2dpk</scene>, resolution 2.50Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, | + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GAI:GUANIDINE'>GAI</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dpk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dpk OCA], [http://www.ebi.ac.uk/pdbsum/2dpk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2dpk RCSB]</span> | ||
}} | }} | ||
| Line 24: | Line 27: | ||
[[Category: Abramson, J.]] | [[Category: Abramson, J.]] | ||
[[Category: Sawaya, M.]] | [[Category: Sawaya, M.]] | ||
| - | [[Category: CA]] | ||
| - | [[Category: EPE]] | ||
| - | [[Category: GAI]] | ||
[[Category: beta-bulge]] | [[Category: beta-bulge]] | ||
[[Category: beta-sandwich]] | [[Category: beta-sandwich]] | ||
| Line 32: | Line 32: | ||
[[Category: cis-proline]] | [[Category: cis-proline]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:37:41 2008'' |
Revision as of 23:37, 30 March 2008
| |||||||
| , resolution 2.50Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
The Crystal Structure of the Primary Ca2+ Sensor of the Na+/Ca2+ Exchanger
Overview
The Na+/Ca2+ exchanger is a plasma membrane protein that regulates intracellular Ca2+ levels in cardiac myocytes. Transport activity is governed by Ca2+, and the primary Ca2+ sensor (CBD1) is located in a large cytoplasmic loop connecting two transmembrane helices. The binding of Ca2+ to the CBD1 sensory domain results in conformational changes that stimulate the exchanger to extrude Ca2+. Here, we present a crystal structure of CBD1 at 2.5A resolution, which reveals a novel Ca2+ binding site consisting of four Ca2+ ions arranged in a tight planar cluster. This intricate coordination pattern for a Ca2+ binding cluster is indicative of a highly sensitive Ca2+ sensor and may represent a general platform for Ca2+ sensing.
About this Structure
2DPK is a Single protein structure of sequence from Canis lupus familiaris. Full crystallographic information is available from OCA.
Reference
The crystal structure of the primary Ca2+ sensor of the Na+/Ca2+ exchanger reveals a novel Ca2+ binding motif., Nicoll DA, Sawaya MR, Kwon S, Cascio D, Philipson KD, Abramson J, J Biol Chem. 2006 Aug 4;281(31):21577-81. Epub 2006 Jun 14. PMID:16774926
Page seeded by OCA on Mon Mar 31 02:37:41 2008
