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1yo4

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Revision as of 08:52, 11 September 2015

Solution Structure of the SARS Coronavirus ORF 7a coded X4 protein

Structural highlights

1yo4 is a 1 chain structure with sequence from Cvhsa. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[NS7A_CVHSA] Non-structural protein which is dispensable for virus replication in cell culture.^[1]

Publication Abstract from PubMed

The SARS related Coronavirus genome contains a variety of novel accessory genes. One of these, called ORF7a or ORF8, code for a protein, known as 7a, U122 or X4. We set out to determine the three-dimensional structure of the soluble ectodomain of this type-I transmembrane protein by nuclear magnetic resonance spectroscopy. The fold of the protein is the first member of a further variation of the immunoglobulin like beta-sandwich fold. Because X4 does not reveal significant sequence homologies to proteins in the data bases, we carried out a structure based similarity search for proteins with known function. High structural similarity to Dl domains of ICAM-1 and ICAM-2, and common features in amino acid sequence between X4 and ICAM-1, suggest X4 to possess binding activity for the alpha(L) integrin I domain of LFA-1. Further, based on this structure based prediction, potential functions of X4 in virus replication and pathogenesis are discussed.

Solution structure of the X4 protein coded by the SARS related coronavirus reveals an immunoglobulin like fold and suggests a binding activity to integrin I domains.,Hanel K, Stangler T, Stoldt M, Willbold D J Biomed Sci. 2006 May;13(3):281-93. Epub 2005 Nov 23. PMID:16328780^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Tan YJ, Fielding BC, Goh PY, Shen S, Tan TH, Lim SG, Hong W. Overexpression of 7a, a protein specifically encoded by the severe acute respiratory syndrome coronavirus, induces apoptosis via a caspase-dependent pathway. J Virol. 2004 Dec;78(24):14043-7. PMID:15564512 doi:http://dx.doi.org/10.1128/JVI.78.24.14043-14047.2004
↑ Hanel K, Stangler T, Stoldt M, Willbold D. Solution structure of the X4 protein coded by the SARS related coronavirus reveals an immunoglobulin like fold and suggests a binding activity to integrin I domains. J Biomed Sci. 2006 May;13(3):281-93. Epub 2005 Nov 23. PMID:16328780 doi:http://dx.doi.org/10.1007/s11373-005-9043-9

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1yo4"

@@ Line 2: / Line 2: @@
 <StructureSection load='1yo4' size='340' side='right' caption='[[1yo4]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1yo4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YO4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YO4 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1yo4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cvhsa Cvhsa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YO4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YO4 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yo4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yo4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yo4 RCSB], [http://www.ebi.ac.uk/pdbsum/1yo4 PDBsum]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yo4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yo4 OCA], [http://pdbe.org/1yo4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yo4 RCSB], [http://www.ebi.ac.uk/pdbsum/1yo4 PDBsum]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/YX4_CVHSA YX4_CVHSA]] Non-structural protein which is dispensable for virus replication in cell culture.<ref>PMID:15564512</ref>
+[[http://www.uniprot.org/uniprot/NS7A_CVHSA NS7A_CVHSA]] Non-structural protein which is dispensable for virus replication in cell culture.<ref>PMID:15564512</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 15: / Line 15: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 1yo4" style="background-color:#fffaf0;"></div>
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Sars coronavirus]]
+[[Category: Cvhsa]]
 [[Category: Haenel, K]]
 [[Category: Stangler, T]]

1yo4

From Proteopedia

Revision as of 08:52, 11 September 2015

Solution Structure of the SARS Coronavirus ORF 7a coded X4 protein

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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