3qr5
From Proteopedia
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==Structure of the first domain of a cardiac Ryanodine Receptor mutant with exon 3 deleted== | ==Structure of the first domain of a cardiac Ryanodine Receptor mutant with exon 3 deleted== | ||
<StructureSection load='3qr5' size='340' side='right' caption='[[3qr5]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='3qr5' size='340' side='right' caption='[[3qr5]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3qr5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3qr5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QR5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QR5 FirstGlance]. <br> |
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3im5|3im5]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3im5|3im5]]</td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ryr2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ryr2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qr5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qr5 RCSB], [http://www.ebi.ac.uk/pdbsum/3qr5 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qr5 OCA], [http://pdbe.org/3qr5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qr5 RCSB], [http://www.ebi.ac.uk/pdbsum/3qr5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qr5 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/ | + | [[http://www.uniprot.org/uniprot/RYR2_MOUSE RYR2_MOUSE]] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.<ref>PMID:10473538</ref> <ref>PMID:9628868</ref> <ref>PMID:21098440</ref> <ref>PMID:20431056</ref> |
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| + | ==See Also== | ||
| + | *[[Ryanodine receptor|Ryanodine receptor]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Lk3 transgenic mice]] |
[[Category: Lobo, P A]] | [[Category: Lobo, P A]] | ||
[[Category: Petegem, F Van]] | [[Category: Petegem, F Van]] | ||
Revision as of 00:27, 5 August 2016
Structure of the first domain of a cardiac Ryanodine Receptor mutant with exon 3 deleted
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