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4i4h
From Proteopedia
(Difference between revisions)
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==Crystal structure of CYP3A4 ligated to pyridine-substituted desoxyritonavir== | ==Crystal structure of CYP3A4 ligated to pyridine-substituted desoxyritonavir== | ||
<StructureSection load='4i4h' size='340' side='right' caption='[[4i4h]], [[Resolution|resolution]] 2.90Å' scene=''> | <StructureSection load='4i4h' size='340' side='right' caption='[[4i4h]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4i4h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[4i4h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I4H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I4H FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=Z9Z:PYRIDIN-3-YLMETHYL+[(2R,5S)-5-{[N-(METHYL{[2-(PROPAN-2-YL)-1,3-THIAZOL-4-YL]METHYL}CARBAMOYL)-D-VALYL]AMINO}-1,6-DIPHENYLHEXAN-2-YL]CARBAMATE'>Z9Z</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=Z9Z:PYRIDIN-3-YLMETHYL+[(2R,5S)-5-{[N-(METHYL{[2-(PROPAN-2-YL)-1,3-THIAZOL-4-YL]METHYL}CARBAMOYL)-D-VALYL]AMINO}-1,6-DIPHENYLHEXAN-2-YL]CARBAMATE'>Z9Z</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3nxu|3nxu]], [[4i4g|4i4g]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3nxu|3nxu]], [[4i4g|4i4g]]</td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP3A4, CYP3A3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP3A4, CYP3A3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i4h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i4h RCSB], [http://www.ebi.ac.uk/pdbsum/4i4h PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i4h OCA], [http://pdbe.org/4i4h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4i4h RCSB], [http://www.ebi.ac.uk/pdbsum/4i4h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4i4h ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 4i4h" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Poulos, T L]] | [[Category: Poulos, T L]] | ||
[[Category: Sevrioukova, I F]] | [[Category: Sevrioukova, I F]] | ||
Revision as of 00:41, 5 August 2016
Crystal structure of CYP3A4 ligated to pyridine-substituted desoxyritonavir
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