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1jvr

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Revision as of 10:53, 11 September 2015

STRUCTURE OF THE HTLV-II MATRIX PROTEIN, NMR, 20 STRUCTURES

Structural highlights

1jvr is a 1 chain structure with sequence from Htlv-2. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[GAG_HTLV2] Matrix protein p19 targets Gag, Gag-Pro and Gag-Pro-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex (By similarity). Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity). Nucleocapsid protein p15 is involved in the packaging and encapsidation of two copies of the genome (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The matrix protein performs similar roles in all retroviruses, initially directing membrane localization of the assembling viral particle and subsequently forming a stable structural shell associated with the inner surface of the mature viral membrane. Although conserved structural elements are likely to perform these functions in all retroviral matrix proteins, invariant motifs are not evident at the primary sequence level and three-dimensional structures have been available for only the primate lentiviral matrix proteins. We have therefore used NMR spectroscopy to determine the structure of the matrix protein from human T-cell leukemia virus type II (HTLV-II), a member of the human oncovirus subclass of retroviruses. A total of 577 distance restraints were used to build 20 refined models that superimpose with an rmsd of 0.71 A for the backbone atoms of the structured regions. The globular HTLV-II matrix structure is composed of four alpha-helices and a 3(10) helix. Exposed basic residues near the C terminus of helix II form a putative membrane binding surface which could act in concert with the N-terminal myristoyl group to anchor the protein on the viral membrane surface. Clear structural similarities between the HTLV-II and HIV-1 matrix proteins suggest that the topology and exposed cationic membrane binding surface are likely to be conserved features of retroviral matrix proteins.

Three-dimensional structure of the HTLV-II matrix protein and comparative analysis of matrix proteins from the different classes of pathogenic human retroviruses.,Christensen AM, Massiah MA, Turner BG, Sundquist WI, Summers MF J Mol Biol. 1996 Dec 20;264(5):1117-31. PMID:9000634^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Christensen AM, Massiah MA, Turner BG, Sundquist WI, Summers MF. Three-dimensional structure of the HTLV-II matrix protein and comparative analysis of matrix proteins from the different classes of pathogenic human retroviruses. J Mol Biol. 1996 Dec 20;264(5):1117-31. PMID:9000634 doi:10.1006/jmbi.1996.0700

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jvr"

@@ Line 2: / Line 2: @@
 <StructureSection load='1jvr' size='340' side='right' caption='[[1jvr]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1jvr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_t-lymphotropic_virus_2 Human t-lymphotropic virus 2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JVR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JVR FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1jvr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Htlv-2 Htlv-2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JVR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JVR FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jvr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jvr RCSB], [http://www.ebi.ac.uk/pdbsum/1jvr PDBsum]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jvr OCA], [http://pdbe.org/1jvr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jvr RCSB], [http://www.ebi.ac.uk/pdbsum/1jvr PDBsum]</span></td></tr>
 </table>
 == Function ==
@@ Line 25: / Line 25: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 1jvr" style="background-color:#fffaf0;"></div>
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human t-lymphotropic virus 2]]
+[[Category: Htlv-2]]
 [[Category: Christensen, A M]]
 [[Category: Massiah, M A]]

1jvr

From Proteopedia

Revision as of 10:53, 11 September 2015

STRUCTURE OF THE HTLV-II MATRIX PROTEIN, NMR, 20 STRUCTURES

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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