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2a2v
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2a2v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chilobrachys_guangxiensis Chilobrachys guangxiensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A2V FirstGlance]. <br> | <table><tr><td colspan='2'>[[2a2v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chilobrachys_guangxiensis Chilobrachys guangxiensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A2V FirstGlance]. <br> | ||
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a2v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2a2v RCSB], [http://www.ebi.ac.uk/pdbsum/2a2v PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a2v OCA], [http://pdbe.org/2a2v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2a2v RCSB], [http://www.ebi.ac.uk/pdbsum/2a2v PDBsum]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/ | + | [[http://www.uniprot.org/uniprot/JZ11A_CHIGU JZ11A_CHIGU]] Inhibits voltage-gated potassium channels (Kv2.1/KCNB1 > Kv4.2/KCND2 > Kv4.1/KCND1). Also inhibits voltage-gated sodium channels of subtype Nav1.5/SCN5A (in cardiac myocytes). The toxin shifts activation towards more depolarized potentials and is suggested to bind to the extracellular S3-S4 loop of the channel. Shows no significant toxic symptoms when injected into mice and into cockroaches.<ref>PMID:17176080</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 11:04, 11 September 2015
The solution structure of Jingzhaotoxin-XI
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