2ea2
From Proteopedia
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|PDB= 2ea2 |SIZE=350|CAPTION= <scene name='initialview01'>2ea2</scene>, resolution 2.50Å | |PDB= 2ea2 |SIZE=350|CAPTION= <scene name='initialview01'>2ea2</scene>, resolution 2.50Å | ||
|SITE= <scene name='pdbsite=AC1:Mn+Binding+Site+For+Residue+A+480'>AC1</scene>, <scene name='pdbsite=AC2:Mn+Binding+Site+For+Residue+A+481'>AC2</scene> and <scene name='pdbsite=AC3:F77+Binding+Site+For+Residue+A+482'>AC3</scene> | |SITE= <scene name='pdbsite=AC1:Mn+Binding+Site+For+Residue+A+480'>AC1</scene>, <scene name='pdbsite=AC2:Mn+Binding+Site+For+Residue+A+481'>AC2</scene> and <scene name='pdbsite=AC3:F77+Binding+Site+For+Residue+A+482'>AC3</scene> | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=F77:3-ETHYL-6-{[(4-FLUOROPHENYL)SULFONYL]AMINO}-2-METHYLBENZOIC+ACID'>F77</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1yw7|1YW7]], [[1yw8|1YW8]], [[1yw9|1YW9]], [[2ga2|2GA2]], [[2ea4|2EA4]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ea2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ea2 OCA], [http://www.ebi.ac.uk/pdbsum/2ea2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ea2 RCSB]</span> | ||
}} | }} | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Park, C H.]] | [[Category: Park, C H.]] | ||
| - | [[Category: F77]] | ||
| - | [[Category: MN]] | ||
[[Category: hydrolase]] | [[Category: hydrolase]] | ||
[[Category: protein-ligand complex]] | [[Category: protein-ligand complex]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:46:01 2008'' |
Revision as of 23:46, 30 March 2008
| |||||||
| , resolution 2.50Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | , and | ||||||
| Ligands: | , | ||||||
| Activity: | Methionyl aminopeptidase, with EC number 3.4.11.18 | ||||||
| Related: | 1YW7, 1YW8, 1YW9, 2GA2, 2EA4
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
h-MetAP2 complexed with A773812
Overview
A series of aryl sulfonamides of 5,6-disubstituted anthranilic acids were identified as potent inhibitors of methionine aminopeptidase-2 (MetAP2). Small alkyl groups and 3-furyl were tolerated at the 5-position of anthranilic acid, while -OCH(3), CH(3), and Cl were found optimal for the 6-position. Placement of 2-aminoethoxy group at the 6-position enabled interaction with the second Mn(2+) but did not result in enhancement in potency. Introduction of a tertiary amino moiety at the ortho-position of the sulfonyl phenyl ring gave reduced protein binding and improved cellular activity, but led to lower oral bioavailability.
About this Structure
2EA2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids., Wang GT, Mantei RA, Kawai M, Tedrow JS, Barnes DM, Wang J, Zhang Q, Lou P, Garcia LA, Bouska J, Yates M, Park C, Judge RA, Lesniewski R, Sheppard GS, Bell RL, Bioorg Med Chem Lett. 2007 May 15;17(10):2817-22. Epub 2007 Feb 25. PMID:17350258
Page seeded by OCA on Mon Mar 31 02:46:01 2008
