This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3e7t
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| + | |||
==Structure of murine iNOS oxygenase domain with inhibitor AR-C102222== | ==Structure of murine iNOS oxygenase domain with inhibitor AR-C102222== | ||
<StructureSection load='3e7t' size='340' side='right' caption='[[3e7t]], [[Resolution|resolution]] 2.60Å' scene=''> | <StructureSection load='3e7t' size='340' side='right' caption='[[3e7t]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3e7t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3e7t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. The January 2011 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Nitric Oxide Synthase'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2011_1 10.2210/rcsb_pdb/mom_2011_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E7T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3E7T FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B14:1-(6-CYANO-3-PYRIDYLCARBONYL)-5,8-DIFLUOROSPIRO[PIPERIDINE-4,2(1H)-QUINAZOLINE]-4-AMINE'>B14</scene>, <scene name='pdbligand=HBI:7,8-DIHYDROBIOPTERIN'>HBI</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B14:1-(6-CYANO-3-PYRIDYLCARBONYL)-5,8-DIFLUOROSPIRO[PIPERIDINE-4,2(1H)-QUINAZOLINE]-4-AMINE'>B14</scene>, <scene name='pdbligand=HBI:7,8-DIHYDROBIOPTERIN'>HBI</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3e65|3e65]], [[3e67|3e67]], [[3e68|3e68]], [[3e6l|3e6l]], [[3e6n|3e6n]], [[3e6o|3e6o]], [[3e6t|3e6t]], [[3e7g|3e7g]], [[3e7i|3e7i]], [[3e7m|3e7m]], [[3e7s|3e7s]], [[3eah|3eah]], [[3eai|3eai]], [[3ebd|3ebd]], [[3ebf|3ebf]], [[3ej8|3ej8]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3e65|3e65]], [[3e67|3e67]], [[3e68|3e68]], [[3e6l|3e6l]], [[3e6n|3e6n]], [[3e6o|3e6o]], [[3e6t|3e6t]], [[3e7g|3e7g]], [[3e7i|3e7i]], [[3e7m|3e7m]], [[3e7s|3e7s]], [[3eah|3eah]], [[3eai|3eai]], [[3ebd|3ebd]], [[3ebf|3ebf]], [[3ej8|3ej8]]</td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Nos2, Inosl ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Nos2, Inosl ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric- | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e7t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3e7t RCSB], [http://www.ebi.ac.uk/pdbsum/3e7t PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e7t OCA], [http://pdbe.org/3e7t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3e7t RCSB], [http://www.ebi.ac.uk/pdbsum/3e7t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3e7t ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| Line 19: | Line 20: | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e7t ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
| Line 29: | Line 30: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 3e7t" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| Line 36: | Line 38: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Lk3 transgenic mice]] |
[[Category: Nitric Oxide Synthase]] | [[Category: Nitric Oxide Synthase]] | ||
| - | [[Category: Nitric-oxide synthase]] | ||
[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
[[Category: Aberg, A]] | [[Category: Aberg, A]] | ||
Revision as of 06:26, 5 August 2016
Structure of murine iNOS oxygenase domain with inhibitor AR-C102222
| |||||||||||
Categories: Lk3 transgenic mice | Nitric Oxide Synthase | RCSB PDB Molecule of the Month | Aberg, A | Andersson, G | Andrews, G | Arvai, A S | Cheshire, D R | Connolly, S | Crane, B R | Garcin, E D | Gensmantel, N P | Getzoff, E D | Hamley, P J | Kroeger, M D | Mallinder, P R | Mete, A | Nicholls, D J | Rosenfeld, R J | St-Gallay, S A | Stuehr, D J | Tainer, J A | Tinker, A C | Wallace, A V | Fad | Fmn | Heme | Iron | Metal-binding | Nadp | Nitric oxide synthase | No | Oxidoreductase | Oxidoreductase calmodulin-binding | Tetrahydrobiopterin
