2eb2
From Proteopedia
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|SITE= | |SITE= | ||
|LIGAND= | |LIGAND= | ||
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span> |
|GENE= EGFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= EGFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2eb3|2EB3]], [[2zge|2ZGE]], [[2zgf|2ZGF]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eb2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eb2 OCA], [http://www.ebi.ac.uk/pdbsum/2eb2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2eb2 RCSB]</span> | ||
}} | }} | ||
'''Crystal structure of mutated EGFR kinase domain (G719S)''' | '''Crystal structure of mutated EGFR kinase domain (G719S)''' | ||
| + | |||
| + | ==Disease== | ||
| + | Known disease associated with this structure: Adenocarcinoma of lung, response to tyrosine kinase inhibitor in OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131550 131550]], Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131550 131550]], Nonsmall cell lung cancer, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131550 131550]] | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: tyrosine-protein kinase]] | [[Category: tyrosine-protein kinase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:46:27 2008'' |
Revision as of 23:46, 30 March 2008
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| , resolution 2.50Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | EGFR (Homo sapiens) | ||||||
| Activity: | Receptor protein-tyrosine kinase, with EC number 2.7.10.1 | ||||||
| Related: | 2EB3, 2ZGE, 2ZGF
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of mutated EGFR kinase domain (G719S)
Disease
Known disease associated with this structure: Adenocarcinoma of lung, response to tyrosine kinase inhibitor in OMIM:[131550], Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in OMIM:[131550], Nonsmall cell lung cancer, susceptibility to OMIM:[131550]
About this Structure
2EB2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Page seeded by OCA on Mon Mar 31 02:46:27 2008
Categories: Homo sapiens | Receptor protein-tyrosine kinase | Single protein | Chen, L. | Kukimoto-Niino, M. | Liu, Z J. | RSGI, RIKEN Structural Genomics/Proteomics Initiative. | Senba, K. | Shirouzu, M. | Wang, B C. | Yamamoto, T. | Yokoyama, S. | Yoshikawa, S. | Atp-binding | Cell cycle | Disease mutation | Ec 2 7.10 1 | Kinase | National project on protein structural and functional analyse | Nppsfa | Phosphorylation | Receptor | Riken structural genomics/proteomics initiative | Rsgi | Structural genomic | Transferase | Transmembrane | Tyrosine-protein kinase
