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2jea

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Revision as of 13:25, 11 September 2015

STRUCTURE OF A 9-SUBUNIT ARCHAEAL EXOSOME BOUND TO RNA

Structural highlights

2jea is a 4 chain structure with sequence from Atcc 35091. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Related:	2jeb, 2c39, 2c37, 2br2, 2c38, 2je6
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[ECR1_SULSO] Probably involved in degradation of a variety of RNA species; could act a RNA-binding component of the exosome (Potential). [ECX1_SULSO] Probably involved in the 3'->5' degradation of a variety of RNA species (Potential).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Exosomes are complexes containing 3' --> 5' exoribonucleases that have important roles in processing, decay and quality control of various RNA molecules. Archaeal exosomes consist of a hexameric core of three active RNase PH subunits (ribosomal RNA processing factor (Rrp)41) and three inactive RNase PH subunits (Rrp42). A trimeric ring of subunits with putative RNA-binding domains (Rrp4/cep1 synthetic lethality (Csl)4) is positioned on top of the hexamer on the opposite side to the RNA degrading sites. Here, we present the 1.6 A resolution crystal structure of the nine-subunit exosome of Sulfolobus solfataricus and the 2.3 A structure of this complex bound to an RNA substrate designed to be partly trimmed rather than completely degraded. The RNA binds both at the active site on one side of the molecule and on the opposite side in the narrowest constriction of the central channel. Multiple substrate-binding sites and the entrapment of the substrate in the central channel provide a rationale for the processive degradation of extended RNAs and the stalling of structured RNAs.

RNA channelling by the archaeal exosome.,Lorentzen E, Dziembowski A, Lindner D, Seraphin B, Conti E EMBO Rep. 2007 May;8(5):470-6. Epub 2007 Mar 23. PMID:17380186^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Lorentzen E, Dziembowski A, Lindner D, Seraphin B, Conti E. RNA channelling by the archaeal exosome. EMBO Rep. 2007 May;8(5):470-6. Epub 2007 Mar 23. PMID:17380186

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2jea"

@@ Line 2: / Line 2: @@
 <StructureSection load='2jea' size='340' side='right' caption='[[2jea]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2jea]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JEA FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2jea]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35091 Atcc 35091]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JEA FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jeb|2jeb]], [[2c39|2c39]], [[2c37|2c37]], [[2br2|2br2]], [[2c38|2c38]], [[2je6|2je6]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jea OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jea RCSB], [http://www.ebi.ac.uk/pdbsum/2jea PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jea OCA], [http://pdbe.org/2jea PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jea RCSB], [http://www.ebi.ac.uk/pdbsum/2jea PDBsum]</span></td></tr>
 </table>
 == Function ==
@@ Line 27: / Line 27: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 2jea" style="background-color:#fffaf0;"></div>
 ==See Also==
 *[[Exonuclease|Exonuclease]]
+*[[Exosome|Exosome]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Sulfolobus solfataricus]]
+[[Category: Atcc 35091]]
 [[Category: Conti, E]]
 [[Category: Lorentzen, E]]

2jea

From Proteopedia

Revision as of 13:25, 11 September 2015

STRUCTURE OF A 9-SUBUNIT ARCHAEAL EXOSOME BOUND TO RNA

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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