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1h9h

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Revision as of 15:22, 11 September 2015

COMPLEX OF EETI-II WITH PORCINE TRYPSIN

Structural highlights

1h9h is a 2 chain structure with sequence from Sus scrofa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Related:	1aks, 1an1, 1avw, 1avx, 1c9p, 1d3o, 1df2, 1eja, 1ept, 1ewu, 1fmg, 1fn6, 1fni, 1ldt, 1lt2, 1mct, 1qqu, 1r0t, 1s5s, 1s6f, 1s6h, 1s81, 1s82, 1s83, 1s84, 1s85, 1tfx
Activity:	Trypsin, with EC number 3.4.21.4
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[ITR2_ECBEL] Inhibits trypsin.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The Ecballium elaterium trypsin inhibitor II (EETI-II) belongs to the family of squash inhibitors and is one of the strongest inhibitors known for trypsin. The eight independent molecules of EETI-II in the crystal structure reported here provide a good opportunity to test the hypothesis that this small cystine-knot protein (knottin) is sufficiently rigid to be used as a molecular scaffold for protein-engineering purposes. To extend this test, the structures of two complexes of EETI-II with trypsin have also been determined, one carrying a four-amino-acid mutation of EETI-II. The remarkable similarity of these structures confirms the rigidity of the molecular framework and hence its suitability as a molecular scaffold.

Structure of Ecballium elaterium trypsin inhibitor II (EETI-II): a rigid molecular scaffold.,Kratzner R, Debreczeni JE, Pape T, Schneider TR, Wentzel A, Kolmar H, Sheldrick GM, Uson I Acta Crystallogr D Biol Crystallogr. 2005 Sep;61(Pt 9):1255-62. Epub 2005, Aug 16. PMID:16131759^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Kratzner R, Debreczeni JE, Pape T, Schneider TR, Wentzel A, Kolmar H, Sheldrick GM, Uson I. Structure of Ecballium elaterium trypsin inhibitor II (EETI-II): a rigid molecular scaffold. Acta Crystallogr D Biol Crystallogr. 2005 Sep;61(Pt 9):1255-62. Epub 2005, Aug 16. PMID:16131759 doi:http://dx.doi.org/10.1107/S0907444905021207

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1h9h"

@@ Line 6: / Line 6: @@
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1aks|1aks]], [[1an1|1an1]], [[1avw|1avw]], [[1avx|1avx]], [[1c9p|1c9p]], [[1d3o|1d3o]], [[1df2|1df2]], [[1eja|1eja]], [[1ept|1ept]], [[1ewu|1ewu]], [[1fmg|1fmg]], [[1fn6|1fn6]], [[1fni|1fni]], [[1ldt|1ldt]], [[1lt2|1lt2]], [[1mct|1mct]], [[1qqu|1qqu]], [[1r0t|1r0t]], [[1s5s|1s5s]], [[1s6f|1s6f]], [[1s6h|1s6h]], [[1s81|1s81]], [[1s82|1s82]], [[1s83|1s83]], [[1s84|1s84]], [[1s85|1s85]], [[1tfx|1tfx]]</td></tr>
 <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h9h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h9h RCSB], [http://www.ebi.ac.uk/pdbsum/1h9h PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h9h OCA], [http://pdbe.org/1h9h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h9h RCSB], [http://www.ebi.ac.uk/pdbsum/1h9h PDBsum]</span></td></tr>
 </table>
 == Function ==
@@ Line 28: / Line 28: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 1h9h" style="background-color:#fffaf0;"></div>
 ==See Also==
 *[[Trypsin|Trypsin]]
+*[[Trypsin inhibitor|Trypsin inhibitor]]
 == References ==
 <references/>

1h9h

From Proteopedia

Revision as of 15:22, 11 September 2015

COMPLEX OF EETI-II WITH PORCINE TRYPSIN

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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