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| - | ==Structural determination of c-Jun N-terminal kinase from Drosophila melanogaster==
| + | #REDIRECT [[5awm]] This PDB entry is obsolete and replaced by 5awm |
| - | <StructureSection load='4m3a' size='340' side='right' caption='[[4m3a]], [[Resolution|resolution]] 1.96Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[4m3a]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M3A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M3A FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m3a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m3a RCSB], [http://www.ebi.ac.uk/pdbsum/4m3a PDBsum]</span></td></tr>
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| - | </table>
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/JNK_DROME JNK_DROME]] Responds to activation by environmental stress by phosphorylating a number of transcription factors, primarily components of AP-1 such as Jra and also the transcriptional repressor aop, and thus regulates transcriptional activity. Component of the immune response activated by bacterial infection, and is involved in wound healing and in dorsal closure, a morphogenetic movement during embryogenesis. Controls the expression of a phosphatase, puckered, at the edges of wounded epidermal tissue and in the dorsal epithelium during dorsal closure.<ref>PMID:8946915</ref> <ref>PMID:9224720</ref> <ref>PMID:10433922</ref> <ref>PMID:11784101</ref>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Mitogen-activated protein kinase]]
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| - | [[Category: Boonserm, P]]
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| - | [[Category: Chimnaronk, S]]
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| - | [[Category: Ketterman, A J]]
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| - | [[Category: Sitthiroongruang, J]]
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| - | [[Category: Atp binding]]
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| - | [[Category: Kinase]]
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| - | [[Category: Phosphorylation]]
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| - | [[Category: Transferase]]
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